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MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE
Administration of Cytoxan in doses capable of inhibiting both humoral and cellular immunity markedly potentiated primary systemic vaccinia virus infection in mice. Immunosuppressed mice did not form neutralizing antibody to vaccinia virus and had a prolonged and more severe viremia than nonimmunosup...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1972
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139199/ https://www.ncbi.nlm.nih.gov/pubmed/5043413 |
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author | Worthington, M. Rabson, A. S. Baron, S. |
author_facet | Worthington, M. Rabson, A. S. Baron, S. |
author_sort | Worthington, M. |
collection | PubMed |
description | Administration of Cytoxan in doses capable of inhibiting both humoral and cellular immunity markedly potentiated primary systemic vaccinia virus infection in mice. Immunosuppressed mice did not form neutralizing antibody to vaccinia virus and had a prolonged and more severe viremia than nonimmunosuppressed control mice. Passive transfer of physiologic amounts of neutralizing antibody late in the course of infection, at a time when nonimmunosuppressed mice had similar levels of serum antibody, largely reversed the effect of Cytoxan on vaccinia virus infection. Transfer of 100 million immune spleen cells was much less effective than antibody in reversing the effect of Cytoxan on vaccinia virus infection, and mice receiving these cells did make some antibody. Serum interferon levels were not affected by Cytoxan. The results suggest an essential role for humoral antibody, but not for cellular immunity, in recovery from primary vaccinia virus infection in the mouse. |
format | Text |
id | pubmed-2139199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1972 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21391992008-04-17 MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE Worthington, M. Rabson, A. S. Baron, S. J Exp Med Article Administration of Cytoxan in doses capable of inhibiting both humoral and cellular immunity markedly potentiated primary systemic vaccinia virus infection in mice. Immunosuppressed mice did not form neutralizing antibody to vaccinia virus and had a prolonged and more severe viremia than nonimmunosuppressed control mice. Passive transfer of physiologic amounts of neutralizing antibody late in the course of infection, at a time when nonimmunosuppressed mice had similar levels of serum antibody, largely reversed the effect of Cytoxan on vaccinia virus infection. Transfer of 100 million immune spleen cells was much less effective than antibody in reversing the effect of Cytoxan on vaccinia virus infection, and mice receiving these cells did make some antibody. Serum interferon levels were not affected by Cytoxan. The results suggest an essential role for humoral antibody, but not for cellular immunity, in recovery from primary vaccinia virus infection in the mouse. The Rockefeller University Press 1972-08-01 /pmc/articles/PMC2139199/ /pubmed/5043413 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Worthington, M. Rabson, A. S. Baron, S. MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title | MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title_full | MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title_fullStr | MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title_full_unstemmed | MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title_short | MECHANISM OF RECOVERY FROM SYSTEMIC VACCINIA VIRUS INFECTION : I. THE EFFECTS OF CYCLOPHOSPHAMIDE |
title_sort | mechanism of recovery from systemic vaccinia virus infection : i. the effects of cyclophosphamide |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139199/ https://www.ncbi.nlm.nih.gov/pubmed/5043413 |
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