RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT

Conventional (cv) and germfree (gf) mice are able to give a good proliferative response to allogeneic cells in the mixed leukocyte culture (MLC) test, while the response to xenogeneic stimulating cells has been in question. Previous studies by others have suggested only a low MLC response in cv anim...

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Detalles Bibliográficos
Autores principales: Widmer, Michael B., Sondel, Paul M., Bach, Fritz H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139209/
https://www.ncbi.nlm.nih.gov/pubmed/5065082
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author Widmer, Michael B.
Sondel, Paul M.
Bach, Fritz H.
author_facet Widmer, Michael B.
Sondel, Paul M.
Bach, Fritz H.
author_sort Widmer, Michael B.
collection PubMed
description Conventional (cv) and germfree (gf) mice are able to give a good proliferative response to allogeneic cells in the mixed leukocyte culture (MLC) test, while the response to xenogeneic stimulating cells has been in question. Previous studies by others have suggested only a low MLC response in cv animals and none in gf ones. We have found that both cv and gf animals can give a good MLC response to xenogeneic as well as allogeneic cells. These findings are of importance for our understanding of both MLC stimulation and response.
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spelling pubmed-21392092008-04-17 RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT Widmer, Michael B. Sondel, Paul M. Bach, Fritz H. J Exp Med Brief Definitive Reports Conventional (cv) and germfree (gf) mice are able to give a good proliferative response to allogeneic cells in the mixed leukocyte culture (MLC) test, while the response to xenogeneic stimulating cells has been in question. Previous studies by others have suggested only a low MLC response in cv animals and none in gf ones. We have found that both cv and gf animals can give a good MLC response to xenogeneic as well as allogeneic cells. These findings are of importance for our understanding of both MLC stimulation and response. The Rockefeller University Press 1972-08-01 /pmc/articles/PMC2139209/ /pubmed/5065082 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Widmer, Michael B.
Sondel, Paul M.
Bach, Fritz H.
RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title_full RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title_fullStr RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title_full_unstemmed RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title_short RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT
title_sort responsiveness of germfree mice in mixed leukocyte culture : reexamining the nature of the responding unit
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139209/
https://www.ncbi.nlm.nih.gov/pubmed/5065082
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AT sondelpaulm responsivenessofgermfreemiceinmixedleukocyteculturereexaminingthenatureoftherespondingunit
AT bachfritzh responsivenessofgermfreemiceinmixedleukocyteculturereexaminingthenatureoftherespondingunit

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