DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE

Exposure of normal mouse spleen cells in vitro to highly (125)I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier t...

Descripción completa

Detalles Bibliográficos
Autores principales: Golan, Dov Theo, Borel, Yves
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139210/
https://www.ncbi.nlm.nih.gov/pubmed/4557771
_version_ 1782143743065849856
author Golan, Dov Theo
Borel, Yves
author_facet Golan, Dov Theo
Borel, Yves
author_sort Golan, Dov Theo
collection PubMed
description Exposure of normal mouse spleen cells in vitro to highly (125)I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier to which the hapten was bound. DNP-binding cells were inactivated by radioactivity that was not part of the hapten, but was solely confined to the carrier moiety. The deletion of the anti-DNP response lasted 2–3 wk and could be specifically inhibited.
format Text
id pubmed-2139210
institution National Center for Biotechnology Information
language English
publishDate 1972
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21392102008-04-17 DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE Golan, Dov Theo Borel, Yves J Exp Med Article Exposure of normal mouse spleen cells in vitro to highly (125)I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier to which the hapten was bound. DNP-binding cells were inactivated by radioactivity that was not part of the hapten, but was solely confined to the carrier moiety. The deletion of the anti-DNP response lasted 2–3 wk and could be specifically inhibited. The Rockefeller University Press 1972-08-01 /pmc/articles/PMC2139210/ /pubmed/4557771 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Golan, Dov Theo
Borel, Yves
DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title_full DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title_fullStr DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title_full_unstemmed DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title_short DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE (125)I CONJUGATE
title_sort deletion of hapten-binding cells by a highly radioactive (125)i conjugate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139210/
https://www.ncbi.nlm.nih.gov/pubmed/4557771
work_keys_str_mv AT golandovtheo deletionofhaptenbindingcellsbyahighlyradioactive125iconjugate
AT borelyves deletionofhaptenbindingcellsbyahighlyradioactive125iconjugate

Ejemplares similares