ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE

Radioautographic study of the binding of GAT-(125)I to spleen cells of genetic responder and nonresponder mice demonstrates that among mice not injected with antigen all strains have approximately the same number of antigen-binding cells; after injection with antigen the number of antigen-binding ce...

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Detalles Bibliográficos
Autores principales: Dunham, Edward K., Unanue, Emil R., Benacerraf, Baruj
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139212/
https://www.ncbi.nlm.nih.gov/pubmed/5043419
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author Dunham, Edward K.
Unanue, Emil R.
Benacerraf, Baruj
author_facet Dunham, Edward K.
Unanue, Emil R.
Benacerraf, Baruj
author_sort Dunham, Edward K.
collection PubMed
description Radioautographic study of the binding of GAT-(125)I to spleen cells of genetic responder and nonresponder mice demonstrates that among mice not injected with antigen all strains have approximately the same number of antigen-binding cells; after injection with antigen the number of antigen-binding cells increases in responders but not in nonresponders. Nonresponders are shown to make antibody after injection with GAT complexed with an immunogenic carrier, demonstrating the presence of potentially functional B cells in responders and nonresponders alike. When incubated in the warm, antigen-binding cells of both responders and nonresponders concentrate antigen at one pole of the cell, forming caps.
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spelling pubmed-21392122008-04-17 ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE Dunham, Edward K. Unanue, Emil R. Benacerraf, Baruj J Exp Med Brief Definitive Reports Radioautographic study of the binding of GAT-(125)I to spleen cells of genetic responder and nonresponder mice demonstrates that among mice not injected with antigen all strains have approximately the same number of antigen-binding cells; after injection with antigen the number of antigen-binding cells increases in responders but not in nonresponders. Nonresponders are shown to make antibody after injection with GAT complexed with an immunogenic carrier, demonstrating the presence of potentially functional B cells in responders and nonresponders alike. When incubated in the warm, antigen-binding cells of both responders and nonresponders concentrate antigen at one pole of the cell, forming caps. The Rockefeller University Press 1972-08-01 /pmc/articles/PMC2139212/ /pubmed/5043419 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Dunham, Edward K.
Unanue, Emil R.
Benacerraf, Baruj
ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title_full ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title_fullStr ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title_full_unstemmed ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title_short ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE
title_sort antigen binding and capping by lymphocytes of genetic nonresponder mice
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139212/
https://www.ncbi.nlm.nih.gov/pubmed/5043419
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AT unanueemilr antigenbindingandcappingbylymphocytesofgeneticnonrespondermice
AT benacerrafbaruj antigenbindingandcappingbylymphocytesofgeneticnonrespondermice

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