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HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION
Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F(1) hybrid (H-2(q/k)) from mating a susceptible SWR/J mouse (H...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1973
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139246/ https://www.ncbi.nlm.nih.gov/pubmed/4702099 |
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author | Oldstone, Michael B. A. Dixon, Frank J. Mitchell, Graham F. McDevitt, Hugh O. |
author_facet | Oldstone, Michael B. A. Dixon, Frank J. Mitchell, Graham F. McDevitt, Hugh O. |
author_sort | Oldstone, Michael B. A. |
collection | PubMed |
description | Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F(1) hybrid (H-2(q/k)) from mating a susceptible SWR/J mouse (H-2(q/q)) to a resistant C3H/HeJ mouse (H-2(k/k)) is susceptible to LCM virus disease. When such hybrids (H-2(q/k)) are backcrossed to susceptible parents (H-2(q/q)), all F(2) offspring (H-2(q/q), H-2(q/k)) are highly susceptible. In contrast, hybrid (H-2(q/k)) backcross to resistant parents (H-2(k/k)) results in half of the F (2) offspring being susceptible (H-2(q/k)) while the other half are resistant (H-2(k/k)). Similarly, in congenic H-2(q/q) and H-2(k/k) mice, H-2(q/q) mice are relatively susceptible to acute LCM disease, whereas H-2(k/k) are resistant. |
format | Text |
id | pubmed-2139246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1973 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21392462008-04-17 HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION Oldstone, Michael B. A. Dixon, Frank J. Mitchell, Graham F. McDevitt, Hugh O. J Exp Med Article Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F(1) hybrid (H-2(q/k)) from mating a susceptible SWR/J mouse (H-2(q/q)) to a resistant C3H/HeJ mouse (H-2(k/k)) is susceptible to LCM virus disease. When such hybrids (H-2(q/k)) are backcrossed to susceptible parents (H-2(q/q)), all F(2) offspring (H-2(q/q), H-2(q/k)) are highly susceptible. In contrast, hybrid (H-2(q/k)) backcross to resistant parents (H-2(k/k)) results in half of the F (2) offspring being susceptible (H-2(q/k)) while the other half are resistant (H-2(k/k)). Similarly, in congenic H-2(q/q) and H-2(k/k) mice, H-2(q/q) mice are relatively susceptible to acute LCM disease, whereas H-2(k/k) are resistant. The Rockefeller University Press 1973-05-01 /pmc/articles/PMC2139246/ /pubmed/4702099 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Oldstone, Michael B. A. Dixon, Frank J. Mitchell, Graham F. McDevitt, Hugh O. HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title | HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title_full | HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title_fullStr | HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title_full_unstemmed | HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title_short | HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY : MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION |
title_sort | histocompatibility-linked genetic control of disease susceptibility : murine lymphocytic choriomeningitis virus injection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139246/ https://www.ncbi.nlm.nih.gov/pubmed/4702099 |
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