THE HURLER SYNDROME: A STUDY OF CULTURED LYMPHOID CELL LINES

Lymphoid suspension lines have been established from three patients with the Hurler syndrome and four normals. The Hurler lines can be distinguished from normals by (a) staining characteristics, (b) increase in total cellular mucopolysaccharide content, and (c) increase in dermatan sulfate. Hyaluron...

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Detalles Bibliográficos
Autores principales: Danes, B. Shannon, Hütteroth, T. H., Cleve, H., Bearn, Alexander G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139258/
https://www.ncbi.nlm.nih.gov/pubmed/4115134
Descripción
Sumario:Lymphoid suspension lines have been established from three patients with the Hurler syndrome and four normals. The Hurler lines can be distinguished from normals by (a) staining characteristics, (b) increase in total cellular mucopolysaccharide content, and (c) increase in dermatan sulfate. Hyaluronic acid is absent in cultured lymphoid cells from normal persons and patients with the Hurler syndrome. The availability of biochemically marked suspension cultures should prove useful for enzymatic studies as well as for further elucidation of this clinical syndrome.

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