CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING

Mice primed to horse erythrocytes (HRBC) produced greatly enhanced 3,5-dinitro,4-hydroxyphenylacetic (NNP)-specific indirect plaque-forming cell (7S PFC) responses when given NNP.HRBC but no difference in hapten-specific direct (19S PFC) responses in comparison to non-carrier-primed mice. The effect...

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Detalles Bibliográficos
Autores principales: Cheers, Christina, Miller, J. F. A. P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139325/
https://www.ncbi.nlm.nih.gov/pubmed/4118416
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author Cheers, Christina
Miller, J. F. A. P.
author_facet Cheers, Christina
Miller, J. F. A. P.
author_sort Cheers, Christina
collection PubMed
description Mice primed to horse erythrocytes (HRBC) produced greatly enhanced 3,5-dinitro,4-hydroxyphenylacetic (NNP)-specific indirect plaque-forming cell (7S PFC) responses when given NNP.HRBC but no difference in hapten-specific direct (19S PFC) responses in comparison to non-carrier-primed mice. The effect was carrier specific and could not be produced by simultaneous challenge of rabbit erythrocyte (RRBC)-primed mice with RRBC and NNP.HRBC. When spleen cells from HRBC-primed mice were transferred to irradiated recipients, there was again an enhanced 7S response to NNP.HRBC. The primed spleen cells could be replaced by giving activated thymus cells to HRBC together with normal spleen as a source of B cells. It is concluded that T cells influence not only the amount but also the class of antibody formed by hapten-sensitive B cells.
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spelling pubmed-21393252008-04-17 CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING Cheers, Christina Miller, J. F. A. P. J Exp Med Brief Definitive Reports Mice primed to horse erythrocytes (HRBC) produced greatly enhanced 3,5-dinitro,4-hydroxyphenylacetic (NNP)-specific indirect plaque-forming cell (7S PFC) responses when given NNP.HRBC but no difference in hapten-specific direct (19S PFC) responses in comparison to non-carrier-primed mice. The effect was carrier specific and could not be produced by simultaneous challenge of rabbit erythrocyte (RRBC)-primed mice with RRBC and NNP.HRBC. When spleen cells from HRBC-primed mice were transferred to irradiated recipients, there was again an enhanced 7S response to NNP.HRBC. The primed spleen cells could be replaced by giving activated thymus cells to HRBC together with normal spleen as a source of B cells. It is concluded that T cells influence not only the amount but also the class of antibody formed by hapten-sensitive B cells. The Rockefeller University Press 1972-11-30 /pmc/articles/PMC2139325/ /pubmed/4118416 Text en Copyright © 1972 by The Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Cheers, Christina
Miller, J. F. A. P.
CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title_full CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title_fullStr CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title_full_unstemmed CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title_short CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : IX. REGULATION OF HAPTEN-SPECIFIC ANTIBODY CLASS BY CARRIER PRIMING
title_sort cell-to-cell interaction in the immune response : ix. regulation of hapten-specific antibody class by carrier priming
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139325/
https://www.ncbi.nlm.nih.gov/pubmed/4118416
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