EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES

Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals w...

Descripción completa

Detalles Bibliográficos
Autores principales: Shope, Thomas, Miller, George
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139357/
https://www.ncbi.nlm.nih.gov/pubmed/4347289
_version_ 1782143777305001984
author Shope, Thomas
Miller, George
author_facet Shope, Thomas
Miller, George
author_sort Shope, Thomas
collection PubMed
description Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane.
format Text
id pubmed-2139357
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21393572008-04-17 EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES Shope, Thomas Miller, George J Exp Med Article Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane. The Rockefeller University Press 1973-01-01 /pmc/articles/PMC2139357/ /pubmed/4347289 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Shope, Thomas
Miller, George
EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title_full EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title_fullStr EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title_full_unstemmed EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title_short EPSTEIN-BARR VIRUS : HETEROPHILE RESPONSES IN SQUIRREL MONKEYS INOCULATED WITH VIRUS-TRANSFORMED AUTOLOGOUS LEUKOCYTES
title_sort epstein-barr virus : heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139357/
https://www.ncbi.nlm.nih.gov/pubmed/4347289
work_keys_str_mv AT shopethomas epsteinbarrvirusheterophileresponsesinsquirrelmonkeysinoculatedwithvirustransformedautologousleukocytes
AT millergeorge epsteinbarrvirusheterophileresponsesinsquirrelmonkeysinoculatedwithvirustransformedautologousleukocytes

Ejemplares similares