RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES

A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immu...

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Detalles Bibliográficos
Autores principales: Parks, Wade P., Livingston, David M., Todaro, George J., Benveniste, Raoul E., Scolnick, Edward M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139374/
https://www.ncbi.nlm.nih.gov/pubmed/4347595
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author Parks, Wade P.
Livingston, David M.
Todaro, George J.
Benveniste, Raoul E.
Scolnick, Edward M.
author_facet Parks, Wade P.
Livingston, David M.
Todaro, George J.
Benveniste, Raoul E.
Scolnick, Edward M.
author_sort Parks, Wade P.
collection PubMed
description A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. These findings combined with the finding of viral-specific RNA indicate that portions of the viral genome are being expressed with a much greater frequency than previously appreciated.
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spelling pubmed-21393742008-04-17 RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES Parks, Wade P. Livingston, David M. Todaro, George J. Benveniste, Raoul E. Scolnick, Edward M. J Exp Med Article A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. These findings combined with the finding of viral-specific RNA indicate that portions of the viral genome are being expressed with a much greater frequency than previously appreciated. The Rockefeller University Press 1973-02-28 /pmc/articles/PMC2139374/ /pubmed/4347595 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Parks, Wade P.
Livingston, David M.
Todaro, George J.
Benveniste, Raoul E.
Scolnick, Edward M.
RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title_full RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title_fullStr RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title_full_unstemmed RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title_short RADIOIMMUNOASSAY OF MAMMALIAN TYPE C VIRAL PROTEINS : III. DETECTION OF VIRAL ANTIGEN IN NORMAL MURINE CELLS AND TISSUES
title_sort radioimmunoassay of mammalian type c viral proteins : iii. detection of viral antigen in normal murine cells and tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139374/
https://www.ncbi.nlm.nih.gov/pubmed/4347595
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