Cargando…

LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS

Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell prepar...

Descripción completa

Detalles Bibliográficos
Autor principal: Weksler, Marc E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139376/
https://www.ncbi.nlm.nih.gov/pubmed/4689338
_version_ 1782143781728944128
author Weksler, Marc E.
author_facet Weksler, Marc E.
author_sort Weksler, Marc E.
collection PubMed
description Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation.
format Text
id pubmed-2139376
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21393762008-04-17 LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS Weksler, Marc E. J Exp Med Article Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation. The Rockefeller University Press 1973-02-28 /pmc/articles/PMC2139376/ /pubmed/4689338 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Weksler, Marc E.
LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title_full LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title_fullStr LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title_full_unstemmed LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title_short LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
title_sort lymphocyte transformation induced by autologous cells : ii. stimulation by mitogen-induced lymphoblasts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139376/
https://www.ncbi.nlm.nih.gov/pubmed/4689338
work_keys_str_mv AT wekslermarce lymphocytetransformationinducedbyautologouscellsiistimulationbymitogeninducedlymphoblasts