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LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS
Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell prepar...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1973
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139376/ https://www.ncbi.nlm.nih.gov/pubmed/4689338 |
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author | Weksler, Marc E. |
author_facet | Weksler, Marc E. |
author_sort | Weksler, Marc E. |
collection | PubMed |
description | Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation. |
format | Text |
id | pubmed-2139376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1973 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21393762008-04-17 LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS Weksler, Marc E. J Exp Med Article Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation. The Rockefeller University Press 1973-02-28 /pmc/articles/PMC2139376/ /pubmed/4689338 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Weksler, Marc E. LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title | LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title_full | LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title_fullStr | LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title_full_unstemmed | LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title_short | LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS : II. STIMULATION BY MITOGEN-INDUCED LYMPHOBLASTS |
title_sort | lymphocyte transformation induced by autologous cells : ii. stimulation by mitogen-induced lymphoblasts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139376/ https://www.ncbi.nlm.nih.gov/pubmed/4689338 |
work_keys_str_mv | AT wekslermarce lymphocytetransformationinducedbyautologouscellsiistimulationbymitogeninducedlymphoblasts |