DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW

An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation....

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Detalles Bibliográficos
Autores principales: El-Arini, M. O., Osoba, D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139385/
https://www.ncbi.nlm.nih.gov/pubmed/4266014
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author El-Arini, M. O.
Osoba, D.
author_facet El-Arini, M. O.
Osoba, D.
author_sort El-Arini, M. O.
collection PubMed
description An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation. Thus, normal bone marrow contains a class of cells that are progeniotrs of T cells (PT cells). PT cells are different from T cells since PT cells are incapable of responding to alloantigen, are θ resistant, and band in a lighter density region than do T cells. The density profile of PT cells is different from that of hematopoietic stem cells (CFU-S); PT cells band in a denser region of the gradient than do CFU-S.
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spelling pubmed-21393852008-04-17 DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW El-Arini, M. O. Osoba, D. J Exp Med Article An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation. Thus, normal bone marrow contains a class of cells that are progeniotrs of T cells (PT cells). PT cells are different from T cells since PT cells are incapable of responding to alloantigen, are θ resistant, and band in a lighter density region than do T cells. The density profile of PT cells is different from that of hematopoietic stem cells (CFU-S); PT cells band in a denser region of the gradient than do CFU-S. The Rockefeller University Press 1973-02-28 /pmc/articles/PMC2139385/ /pubmed/4266014 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
El-Arini, M. O.
Osoba, D.
DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title_full DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title_fullStr DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title_full_unstemmed DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title_short DIFFERENTIATION OF THYMUS-DERIVED CELLS FROM PRECURSORS IN MOUSE BONE MARROW
title_sort differentiation of thymus-derived cells from precursors in mouse bone marrow
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139385/
https://www.ncbi.nlm.nih.gov/pubmed/4266014
work_keys_str_mv AT elarinimo differentiationofthymusderivedcellsfromprecursorsinmousebonemarrow
AT osobad differentiationofthymusderivedcellsfromprecursorsinmousebonemarrow

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