MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY

A variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (BrdU) treatment of an nonproducer (NP) cell line transformed by the Kirsten strain of murine sarcoma virus (Ki-MSV). Isolation procedures of these cell See PDF for Structure mutants are described. The cell mutants obtaine...

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Detalles Bibliográficos
Autores principales: Hatanaka, M., Klein, R., Toni, R., Walker, J., Gilden, R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139394/
https://www.ncbi.nlm.nih.gov/pubmed/4352583
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author Hatanaka, M.
Klein, R.
Toni, R.
Walker, J.
Gilden, R.
author_facet Hatanaka, M.
Klein, R.
Toni, R.
Walker, J.
Gilden, R.
author_sort Hatanaka, M.
collection PubMed
description A variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (BrdU) treatment of an nonproducer (NP) cell line transformed by the Kirsten strain of murine sarcoma virus (Ki-MSV). Isolation procedures of these cell See PDF for Structure mutants are described. The cell mutants obtained were classified by tumorigenic potential and shedding of Type C virus particles. The cell mutants were classified into four groups: (A) tumorigenic, without particles; (B) tumorigenic, with Type C particles; (C) nontumorigenic, without particles; and (D) nontumorigenic, with Type C particles. The tumorigenic cell lines showed variability in morphology with both flat and typical transformed appearing cell lines showing equal transplantability.
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spelling pubmed-21393942008-04-17 MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY Hatanaka, M. Klein, R. Toni, R. Walker, J. Gilden, R. J Exp Med Article A variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (BrdU) treatment of an nonproducer (NP) cell line transformed by the Kirsten strain of murine sarcoma virus (Ki-MSV). Isolation procedures of these cell See PDF for Structure mutants are described. The cell mutants obtained were classified by tumorigenic potential and shedding of Type C virus particles. The cell mutants were classified into four groups: (A) tumorigenic, without particles; (B) tumorigenic, with Type C particles; (C) nontumorigenic, without particles; and (D) nontumorigenic, with Type C particles. The tumorigenic cell lines showed variability in morphology with both flat and typical transformed appearing cell lines showing equal transplantability. The Rockefeller University Press 1973-08-01 /pmc/articles/PMC2139394/ /pubmed/4352583 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hatanaka, M.
Klein, R.
Toni, R.
Walker, J.
Gilden, R.
MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title_full MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title_fullStr MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title_full_unstemmed MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title_short MUTANTS OF NONPRODUCER CELL LINES TRANSFORMED BY MURINE SARCOMA VIRUSES : I. INDUCTION, ISOLATION, PARTICLE PRODUCTION, AND TUMORIGENICITY
title_sort mutants of nonproducer cell lines transformed by murine sarcoma viruses : i. induction, isolation, particle production, and tumorigenicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139394/
https://www.ncbi.nlm.nih.gov/pubmed/4352583
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