THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE

Tritiated thymidine was injected during the neonatal period into conventional CBA mice. The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Mattioli, Carlos A., Tomasi, Thomas B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139405/
https://www.ncbi.nlm.nih.gov/pubmed/4578299
_version_ 1782143788592922624
author Mattioli, Carlos A.
Tomasi, Thomas B.
author_facet Mattioli, Carlos A.
Tomasi, Thomas B.
author_sort Mattioli, Carlos A.
collection PubMed
description Tritiated thymidine was injected during the neonatal period into conventional CBA mice. The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma cells with labeled nuclei. In this way, it was possible to calculate that the major population of intestinal IgA plasma cells have a half-life of 4.7 days under physiological conditions of stimulation. It was also found that the maximum life span of both intestinal IgA plasma cells and the IgA, IgG, and IgM plasma cells from the spleen is of the order of 7–8 wk.
format Text
id pubmed-2139405
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21394052008-04-17 THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE Mattioli, Carlos A. Tomasi, Thomas B. J Exp Med Article Tritiated thymidine was injected during the neonatal period into conventional CBA mice. The disappearance rate of tritium-labeled IgA plasma cells was followed by a technique combining immunofluorescence with autoradiography which permitted the identification of the immunoglobulin class of plasma cells with labeled nuclei. In this way, it was possible to calculate that the major population of intestinal IgA plasma cells have a half-life of 4.7 days under physiological conditions of stimulation. It was also found that the maximum life span of both intestinal IgA plasma cells and the IgA, IgG, and IgM plasma cells from the spleen is of the order of 7–8 wk. The Rockefeller University Press 1973-08-01 /pmc/articles/PMC2139405/ /pubmed/4578299 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Mattioli, Carlos A.
Tomasi, Thomas B.
THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title_full THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title_fullStr THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title_full_unstemmed THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title_short THE LIFE SPAN OF IgA PLASMA CELLS FROM THE MOUSE INTESTINE
title_sort life span of iga plasma cells from the mouse intestine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139405/
https://www.ncbi.nlm.nih.gov/pubmed/4578299
work_keys_str_mv AT mattiolicarlosa thelifespanofigaplasmacellsfromthemouseintestine
AT tomasithomasb thelifespanofigaplasmacellsfromthemouseintestine
AT mattiolicarlosa lifespanofigaplasmacellsfromthemouseintestine
AT tomasithomasb lifespanofigaplasmacellsfromthemouseintestine

Ejemplares similares