STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION

Mixed lymphocyte reactions occur when mouse spleen cell populations depleted of thymus-derived (T) lymphocytes are cultured with allogeneic target cells inactivated by mitomycin C or X irradiation, and when F(1) hybrid responder cells are cultured with inactivated parental target cells. These respon...

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Detalles Bibliográficos
Autores principales: Harrison, Michael R., Paul, William E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139456/
https://www.ncbi.nlm.nih.gov/pubmed/4543459
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author Harrison, Michael R.
Paul, William E.
author_facet Harrison, Michael R.
Paul, William E.
author_sort Harrison, Michael R.
collection PubMed
description Mixed lymphocyte reactions occur when mouse spleen cell populations depleted of thymus-derived (T) lymphocytes are cultured with allogeneic target cells inactivated by mitomycin C or X irradiation, and when F(1) hybrid responder cells are cultured with inactivated parental target cells. These responses might be interpreted as indicating that T lymphocytes are not required for responsiveness and that F(1) lymphocytes recognize parental alloantigens. Data reported here indicate that the more likely explanation for these surprising results is that inactivated target cells recognize the "responding" cells and this recognition leads to the response observed.
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spelling pubmed-21394562008-04-17 STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION Harrison, Michael R. Paul, William E. J Exp Med Brief Definitive Reports Mixed lymphocyte reactions occur when mouse spleen cell populations depleted of thymus-derived (T) lymphocytes are cultured with allogeneic target cells inactivated by mitomycin C or X irradiation, and when F(1) hybrid responder cells are cultured with inactivated parental target cells. These responses might be interpreted as indicating that T lymphocytes are not required for responsiveness and that F(1) lymphocytes recognize parental alloantigens. Data reported here indicate that the more likely explanation for these surprising results is that inactivated target cells recognize the "responding" cells and this recognition leads to the response observed. The Rockefeller University Press 1973-11-30 /pmc/articles/PMC2139456/ /pubmed/4543459 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Harrison, Michael R.
Paul, William E.
STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title_full STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title_fullStr STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title_full_unstemmed STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title_short STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION
title_sort stimulus-response in the mixed lymphocyte reaction
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139456/
https://www.ncbi.nlm.nih.gov/pubmed/4543459
work_keys_str_mv AT harrisonmichaelr stimulusresponseinthemixedlymphocytereaction
AT paulwilliame stimulusresponseinthemixedlymphocytereaction

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