STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR

A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultu...

Descripción completa

Detalles Bibliográficos
Autores principales: Schimpl, A., Wecker, E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139499/
https://www.ncbi.nlm.nih.gov/pubmed/4568302
_version_ 1782143810592047104
author Schimpl, A.
Wecker, E.
author_facet Schimpl, A.
Wecker, E.
author_sort Schimpl, A.
collection PubMed
description A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.
format Text
id pubmed-2139499
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21394992008-04-17 STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR Schimpl, A. Wecker, E. J Exp Med Brief Definitive Reports A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems. The Rockefeller University Press 1973-01-31 /pmc/articles/PMC2139499/ /pubmed/4568302 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Schimpl, A.
Wecker, E.
STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title_full STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title_fullStr STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title_full_unstemmed STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title_short STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
title_sort stimulation of igg antibody response in vitro by t cell-replacing factor
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139499/
https://www.ncbi.nlm.nih.gov/pubmed/4568302
work_keys_str_mv AT schimpla stimulationofiggantibodyresponseinvitrobytcellreplacingfactor
AT weckere stimulationofiggantibodyresponseinvitrobytcellreplacingfactor

Ejemplares similares