IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE

Although most mouse strain combinations succumb to a lethal wasting disease when parabiosed across a strong histocompatibility (H-2) barrier, a high proportion of DBA mice parabiosed to DBA/C3H F(1) hybrids survive and appear healthy. DBA mice accept C3H skin grafts following parabiosis, and may the...

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Detalles Bibliográficos
Autores principales: Shaw, Andrew, Berko, Barbara, Wegmann, Thomas G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139558/
https://www.ncbi.nlm.nih.gov/pubmed/4149644
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author Shaw, Andrew
Berko, Barbara
Wegmann, Thomas G.
author_facet Shaw, Andrew
Berko, Barbara
Wegmann, Thomas G.
author_sort Shaw, Andrew
collection PubMed
description Although most mouse strain combinations succumb to a lethal wasting disease when parabiosed across a strong histocompatibility (H-2) barrier, a high proportion of DBA mice parabiosed to DBA/C3H F(1) hybrids survive and appear healthy. DBA mice accept C3H skin grafts following parabiosis, and may therefore be considered operationally tolerant of C3H antigens. Nonetheless, spleen cells from long-term DBA and F(1) parabionts give normal and enhanced responses, respectively, to C3H antigens in mixed lymphocyte culture (MLC). This indicates that the tolerance mechanism can distinguish between MLC recognition reactivity and in vivo effector reactivity, and that the former can therefore exist in the absence of the latter.
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spelling pubmed-21395582008-04-17 IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE Shaw, Andrew Berko, Barbara Wegmann, Thomas G. J Exp Med Brief Definitive Reports Although most mouse strain combinations succumb to a lethal wasting disease when parabiosed across a strong histocompatibility (H-2) barrier, a high proportion of DBA mice parabiosed to DBA/C3H F(1) hybrids survive and appear healthy. DBA mice accept C3H skin grafts following parabiosis, and may therefore be considered operationally tolerant of C3H antigens. Nonetheless, spleen cells from long-term DBA and F(1) parabionts give normal and enhanced responses, respectively, to C3H antigens in mixed lymphocyte culture (MLC). This indicates that the tolerance mechanism can distinguish between MLC recognition reactivity and in vivo effector reactivity, and that the former can therefore exist in the absence of the latter. The Rockefeller University Press 1974-03-01 /pmc/articles/PMC2139558/ /pubmed/4149644 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Shaw, Andrew
Berko, Barbara
Wegmann, Thomas G.
IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title_full IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title_fullStr IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title_full_unstemmed IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title_short IMMUNOLOGICAL TOLERANCE : DISSOCIATION BETWEEN IN VIVO AND IN VITRO REACTIVITY IN PARABIOSED MICE
title_sort immunological tolerance : dissociation between in vivo and in vitro reactivity in parabiosed mice
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139558/
https://www.ncbi.nlm.nih.gov/pubmed/4149644
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