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THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE

Mice treated with sea star factor (SSF), a protein extracted from sea star coelomocytes, became highly susceptible to infection with a normally sublethal dose of Listeria monocytogenes. This was in contrast to the expected result of increased resistance originally postulated because of the macrophag...

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Detalles Bibliográficos
Autores principales: Willenborg, David O., Prendergast, Robert A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139573/
https://www.ncbi.nlm.nih.gov/pubmed/4205878
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author Willenborg, David O.
Prendergast, Robert A.
author_facet Willenborg, David O.
Prendergast, Robert A.
author_sort Willenborg, David O.
collection PubMed
description Mice treated with sea star factor (SSF), a protein extracted from sea star coelomocytes, became highly susceptible to infection with a normally sublethal dose of Listeria monocytogenes. This was in contrast to the expected result of increased resistance originally postulated because of the macrophage-activating properties of SSF. Enhanced susceptibility was seen when SSF was given from 96 h before to 48 h after infection with Listeria. Mice pretreated with SSF failed to develop immunity to Listeria when given a dose of organisms capable of immunizing nontreated mice. Treatment of immune mice with SSF did not alter their immune status. In addition, incubation of immune lymphocytes with SSF in vitro did not alter their ability to adoptively transfer immunity to normal recipients. Immune lymphocytes treated with SSF and then incubated with anti-SSF and C did, however, lose the ability to transfer immunity. These results suggest that SSF enhances infection by binding to T lymphocytes, inhibiting their replication upon contact with Listeria antigen and thus preventing the generation of a population of sensitized lymphocytes capable of effecting anti-Listeria immunity.
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spelling pubmed-21395732008-04-17 THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE Willenborg, David O. Prendergast, Robert A. J Exp Med Article Mice treated with sea star factor (SSF), a protein extracted from sea star coelomocytes, became highly susceptible to infection with a normally sublethal dose of Listeria monocytogenes. This was in contrast to the expected result of increased resistance originally postulated because of the macrophage-activating properties of SSF. Enhanced susceptibility was seen when SSF was given from 96 h before to 48 h after infection with Listeria. Mice pretreated with SSF failed to develop immunity to Listeria when given a dose of organisms capable of immunizing nontreated mice. Treatment of immune mice with SSF did not alter their immune status. In addition, incubation of immune lymphocytes with SSF in vitro did not alter their ability to adoptively transfer immunity to normal recipients. Immune lymphocytes treated with SSF and then incubated with anti-SSF and C did, however, lose the ability to transfer immunity. These results suggest that SSF enhances infection by binding to T lymphocytes, inhibiting their replication upon contact with Listeria antigen and thus preventing the generation of a population of sensitized lymphocytes capable of effecting anti-Listeria immunity. The Rockefeller University Press 1974-04-01 /pmc/articles/PMC2139573/ /pubmed/4205878 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Willenborg, David O.
Prendergast, Robert A.
THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title_full THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title_fullStr THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title_full_unstemmed THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title_short THE EFFECT OF SEA STAR COELOMOCYTE EXTRACT ON CELL-MEDIATED RESISTANCE TO LISTERIA MONOCYTOGENES IN MICE
title_sort effect of sea star coelomocyte extract on cell-mediated resistance to listeria monocytogenes in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139573/
https://www.ncbi.nlm.nih.gov/pubmed/4205878
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