RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE

The antibody-induced redistribution of β2-microglobulin (β2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all β2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were...

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Detalles Bibliográficos
Autores principales: Neauport-Sautes, C., Bismuth, A., Kourilsky, F. M., Manuel, Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139575/
https://www.ncbi.nlm.nih.gov/pubmed/4131515
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author Neauport-Sautes, C.
Bismuth, A.
Kourilsky, F. M.
Manuel, Y.
author_facet Neauport-Sautes, C.
Bismuth, A.
Kourilsky, F. M.
Manuel, Y.
author_sort Neauport-Sautes, C.
collection PubMed
description The antibody-induced redistribution of β2-microglobulin (β2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all β2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the β2-µ caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable β2-µ molecules. These results suggest that HL-A antigens may be associated with β2-µ at the cell surface, but that all β2-µ molecules are not bound to HL-A antigens.
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spelling pubmed-21395752008-04-17 RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE Neauport-Sautes, C. Bismuth, A. Kourilsky, F. M. Manuel, Y. J Exp Med Article The antibody-induced redistribution of β2-microglobulin (β2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all β2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the β2-µ caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable β2-µ molecules. These results suggest that HL-A antigens may be associated with β2-µ at the cell surface, but that all β2-µ molecules are not bound to HL-A antigens. The Rockefeller University Press 1974-04-01 /pmc/articles/PMC2139575/ /pubmed/4131515 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Neauport-Sautes, C.
Bismuth, A.
Kourilsky, F. M.
Manuel, Y.
RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title_full RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title_fullStr RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title_full_unstemmed RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title_short RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE
title_sort relationship between hl-a antigens and β2-microglobulin as studied by immunofluorescence on the lymphocyte membrane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139575/
https://www.ncbi.nlm.nih.gov/pubmed/4131515
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AT kourilskyfm relationshipbetweenhlaantigensandb2microglobulinasstudiedbyimmunofluorescenceonthelymphocytemembrane
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