A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Using the direct migration inhibition test, response to measles antigen in patients with systemic lupus erythematosus (SLE) was found to be decreased when compared with that of normal subjects. No alteration was observed in similar experiments using parainfluenza type 1 and rubella antigens. The spe...

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Detalles Bibliográficos
Autores principales: Utermohlen, Virginia, Winfield, John B., Zabriskie, John B., Kunkel, Henry G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139577/
https://www.ncbi.nlm.nih.gov/pubmed/4361242
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author Utermohlen, Virginia
Winfield, John B.
Zabriskie, John B.
Kunkel, Henry G.
author_facet Utermohlen, Virginia
Winfield, John B.
Zabriskie, John B.
Kunkel, Henry G.
author_sort Utermohlen, Virginia
collection PubMed
description Using the direct migration inhibition test, response to measles antigen in patients with systemic lupus erythematosus (SLE) was found to be decreased when compared with that of normal subjects. No alteration was observed in similar experiments using parainfluenza type 1 and rubella antigens. The specific decrease in measles antigen effect showed no obvious correlation with activity of SLE or with the presence of lymphocytotoxic antibodies. Whether the specificity of the decrease in reactivity is due to some particular relationship between the measles virus or antigen and SLE, or to the possibility that measles reactivity is a more sensitive indicator of a generalized defect of cell-mediated immunity, remains unclear.
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spelling pubmed-21395772008-04-17 A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Utermohlen, Virginia Winfield, John B. Zabriskie, John B. Kunkel, Henry G. J Exp Med Brief Definitive Reports Using the direct migration inhibition test, response to measles antigen in patients with systemic lupus erythematosus (SLE) was found to be decreased when compared with that of normal subjects. No alteration was observed in similar experiments using parainfluenza type 1 and rubella antigens. The specific decrease in measles antigen effect showed no obvious correlation with activity of SLE or with the presence of lymphocytotoxic antibodies. Whether the specificity of the decrease in reactivity is due to some particular relationship between the measles virus or antigen and SLE, or to the possibility that measles reactivity is a more sensitive indicator of a generalized defect of cell-mediated immunity, remains unclear. The Rockefeller University Press 1974-04-01 /pmc/articles/PMC2139577/ /pubmed/4361242 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Utermohlen, Virginia
Winfield, John B.
Zabriskie, John B.
Kunkel, Henry G.
A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title_full A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title_fullStr A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title_full_unstemmed A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title_short A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
title_sort depression of cell-mediated immunity to measles antigen in patients with systemic lupus erythematosus
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139577/
https://www.ncbi.nlm.nih.gov/pubmed/4361242
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