Cargando…

FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT

Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab co...

Descripción completa

Detalles Bibliográficos
Autores principales: Oldstone, Michael B. A., Cooper, Neil R., Larson, David L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139595/
https://www.ncbi.nlm.nih.gov/pubmed/4367757
_version_ 1782143832978096128
author Oldstone, Michael B. A.
Cooper, Neil R.
Larson, David L.
author_facet Oldstone, Michael B. A.
Cooper, Neil R.
Larson, David L.
author_sort Oldstone, Michael B. A.
collection PubMed
description Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.
format Text
id pubmed-2139595
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21395952008-04-17 FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT Oldstone, Michael B. A. Cooper, Neil R. Larson, David L. J Exp Med Article Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes. The Rockefeller University Press 1974-08-01 /pmc/articles/PMC2139595/ /pubmed/4367757 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Oldstone, Michael B. A.
Cooper, Neil R.
Larson, David L.
FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title_full FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title_fullStr FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title_full_unstemmed FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title_short FORMATION AND BIOLOGIC ROLE OF POLYOMA VIRUS-ANTIBODY COMPLEXES : A CRITICAL ROLE FOR COMPLEMENT
title_sort formation and biologic role of polyoma virus-antibody complexes : a critical role for complement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139595/
https://www.ncbi.nlm.nih.gov/pubmed/4367757
work_keys_str_mv AT oldstonemichaelba formationandbiologicroleofpolyomavirusantibodycomplexesacriticalroleforcomplement
AT cooperneilr formationandbiologicroleofpolyomavirusantibodycomplexesacriticalroleforcomplement
AT larsondavidl formationandbiologicroleofpolyomavirusantibodycomplexesacriticalroleforcomplement