THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES

Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural stud...

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Detalles Bibliográficos
Autor principal: Matter, Alex
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139597/
https://www.ncbi.nlm.nih.gov/pubmed/4152545
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author Matter, Alex
author_facet Matter, Alex
author_sort Matter, Alex
collection PubMed
description Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells.
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spelling pubmed-21395972008-04-17 THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES Matter, Alex J Exp Med Article Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells. The Rockefeller University Press 1974-08-01 /pmc/articles/PMC2139597/ /pubmed/4152545 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Matter, Alex
THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title_full THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title_fullStr THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title_full_unstemmed THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title_short THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES : EVIDENCE FOR TWO DIFFERENTIATED CELL TYPES
title_sort differentiation pathway of t lymphocytes : evidence for two differentiated cell types
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139597/
https://www.ncbi.nlm.nih.gov/pubmed/4152545
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