GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES

Recent data stress the importance of matching donor and recipient of an organ graft for both the serologically defined (SD) and lymphocyte-defined (LD) determinants. To allow experimental evaluation of the effect of these SD and LD structures in a noninbred experimental animal, mixed leukocyte cultu...

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Autores principales: van den Tweel, J. G., Vriesendorp, H. M., Termijtelen, A., Westbroek, D. L., Bach, M. L., van Rood, J. J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139604/
https://www.ncbi.nlm.nih.gov/pubmed/4278110
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author van den Tweel, J. G.
Vriesendorp, H. M.
Termijtelen, A.
Westbroek, D. L.
Bach, M. L.
van Rood, J. J.
author_facet van den Tweel, J. G.
Vriesendorp, H. M.
Termijtelen, A.
Westbroek, D. L.
Bach, M. L.
van Rood, J. J.
author_sort van den Tweel, J. G.
collection PubMed
description Recent data stress the importance of matching donor and recipient of an organ graft for both the serologically defined (SD) and lymphocyte-defined (LD) determinants. To allow experimental evaluation of the effect of these SD and LD structures in a noninbred experimental animal, mixed leukocyte culture tests were performed between SD identical and nonidentical dogs to clarify the LD system in these animals. The results of these experiments can be summarized as follows: (a) In the dog there is a LD locus distinct from the known SD loci, which in all probability is localized outside the first (SD-1) series locus on the chromosome. (b) The crossing-over frequency between the SD and LD loci on the chromosome is low. (c) Studies in SD identical unrelated dogs and random unrelated dogs show an apparent high linkage disequilibrium between SD and LD loci. (d) The LD system in dogs is polymorphic.
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spelling pubmed-21396042008-04-17 GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES van den Tweel, J. G. Vriesendorp, H. M. Termijtelen, A. Westbroek, D. L. Bach, M. L. van Rood, J. J. J Exp Med Article Recent data stress the importance of matching donor and recipient of an organ graft for both the serologically defined (SD) and lymphocyte-defined (LD) determinants. To allow experimental evaluation of the effect of these SD and LD structures in a noninbred experimental animal, mixed leukocyte culture tests were performed between SD identical and nonidentical dogs to clarify the LD system in these animals. The results of these experiments can be summarized as follows: (a) In the dog there is a LD locus distinct from the known SD loci, which in all probability is localized outside the first (SD-1) series locus on the chromosome. (b) The crossing-over frequency between the SD and LD loci on the chromosome is low. (c) Studies in SD identical unrelated dogs and random unrelated dogs show an apparent high linkage disequilibrium between SD and LD loci. (d) The LD system in dogs is polymorphic. The Rockefeller University Press 1974-09-01 /pmc/articles/PMC2139604/ /pubmed/4278110 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
van den Tweel, J. G.
Vriesendorp, H. M.
Termijtelen, A.
Westbroek, D. L.
Bach, M. L.
van Rood, J. J.
GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title_full GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title_fullStr GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title_full_unstemmed GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title_short GENETIC ASPECTS OF CANINE MIXED LEUKOCYTE CULTURES
title_sort genetic aspects of canine mixed leukocyte cultures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139604/
https://www.ncbi.nlm.nih.gov/pubmed/4278110
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