CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES

This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of...

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Detalles Bibliográficos
Autores principales: Dorf, Martin E., Lilly, Frank, Benacerraf, Baruj
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139613/
https://www.ncbi.nlm.nih.gov/pubmed/4412395
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author Dorf, Martin E.
Lilly, Frank
Benacerraf, Baruj
author_facet Dorf, Martin E.
Lilly, Frank
Benacerraf, Baruj
author_sort Dorf, Martin E.
collection PubMed
description This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLφ). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLφ gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed.
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spelling pubmed-21396132008-04-17 CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES Dorf, Martin E. Lilly, Frank Benacerraf, Baruj J Exp Med Brief Definitive Reports This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLφ). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLφ gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed. The Rockefeller University Press 1974-09-01 /pmc/articles/PMC2139613/ /pubmed/4412395 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Dorf, Martin E.
Lilly, Frank
Benacerraf, Baruj
CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title_full CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title_fullStr CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title_full_unstemmed CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title_short CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THEIr-REANDIr-GLT GENES
title_sort characterization of a new intra-h-2 recombinant : separation of their-reandir-glt genes
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139613/
https://www.ncbi.nlm.nih.gov/pubmed/4412395
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AT benacerrafbaruj characterizationofanewintrah2recombinantseparationoftheirreandirgltgenes

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