EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT

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HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants wer...

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Detalles Bibliográficos
Autores principales: Fu, S. M., Kunkel, H. G., Brusman, H. P., Allen, F. H., Fotino, M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139628/
https://www.ncbi.nlm.nih.gov/pubmed/4427089
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author Fu, S. M.
Kunkel, H. G.
Brusman, H. P.
Allen, F. H.
Fotino, M.
author_facet Fu, S. M.
Kunkel, H. G.
Brusman, H. P.
Allen, F. H.
Fotino, M.
author_sort Fu, S. M.
collection PubMed
description HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.
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spelling pubmed-21396282008-04-17 EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT Fu, S. M. Kunkel, H. G. Brusman, H. P. Allen, F. H. Fotino, M. J Exp Med Brief Definitive Reports HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed. The Rockefeller University Press 1974-10-01 /pmc/articles/PMC2139628/ /pubmed/4427089 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Fu, S. M.
Kunkel, H. G.
Brusman, H. P.
Allen, F. H.
Fotino, M.
EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title_full EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title_fullStr EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title_full_unstemmed EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title_short EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT
title_sort evidence for linkage between hl-a histocompatibility genes and those involved in the synthesis of the second component of complement
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139628/
https://www.ncbi.nlm.nih.gov/pubmed/4427089
work_keys_str_mv AT fusm evidenceforlinkagebetweenhlahistocompatibilitygenesandthoseinvolvedinthesynthesisofthesecondcomponentofcomplement
AT kunkelhg evidenceforlinkagebetweenhlahistocompatibilitygenesandthoseinvolvedinthesynthesisofthesecondcomponentofcomplement
AT brusmanhp evidenceforlinkagebetweenhlahistocompatibilitygenesandthoseinvolvedinthesynthesisofthesecondcomponentofcomplement
AT allenfh evidenceforlinkagebetweenhlahistocompatibilitygenesandthoseinvolvedinthesynthesisofthesecondcomponentofcomplement
AT fotinom evidenceforlinkagebetweenhlahistocompatibilitygenesandthoseinvolvedinthesynthesisofthesecondcomponentofcomplement

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