HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP

The capacity of normal human T lymphocytes to form rosettes with sheep red blood cells can be inhibited by drugs or agents which induce elevations in intracellular levels of cyclic AMP. The effect is early in the presence of agents which elicit rapid elevations in intracellular cyclic AMP (isoproter...

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Detalles Bibliográficos
Autores principales: Chisari, Francis V., Edgington, Thomas S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139637/
https://www.ncbi.nlm.nih.gov/pubmed/4372291
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author Chisari, Francis V.
Edgington, Thomas S.
author_facet Chisari, Francis V.
Edgington, Thomas S.
author_sort Chisari, Francis V.
collection PubMed
description The capacity of normal human T lymphocytes to form rosettes with sheep red blood cells can be inhibited by drugs or agents which induce elevations in intracellular levels of cyclic AMP. The effect is early in the presence of agents which elicit rapid elevations in intracellular cyclic AMP (isoproterenol, aminophylline) and occurs later in the presence of cholera toxin which induces a dalayed increase in endogenous cyclic AMP. Dibutyryl cyclic AMP is inhibitory, and the effects of dibutyryl cyclic AMP and the adenyl cyclase stimulators are potentiated by inhibition of phosphodiesterase. These data provide substantial evidence that elevation of intracellular cyclic AMP diminishes E rosette function of lymphocytes.
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spelling pubmed-21396372008-04-17 HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP Chisari, Francis V. Edgington, Thomas S. J Exp Med Brief Definitive Reports The capacity of normal human T lymphocytes to form rosettes with sheep red blood cells can be inhibited by drugs or agents which induce elevations in intracellular levels of cyclic AMP. The effect is early in the presence of agents which elicit rapid elevations in intracellular cyclic AMP (isoproterenol, aminophylline) and occurs later in the presence of cholera toxin which induces a dalayed increase in endogenous cyclic AMP. Dibutyryl cyclic AMP is inhibitory, and the effects of dibutyryl cyclic AMP and the adenyl cyclase stimulators are potentiated by inhibition of phosphodiesterase. These data provide substantial evidence that elevation of intracellular cyclic AMP diminishes E rosette function of lymphocytes. The Rockefeller University Press 1974-10-01 /pmc/articles/PMC2139637/ /pubmed/4372291 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Chisari, Francis V.
Edgington, Thomas S.
HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title_full HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title_fullStr HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title_full_unstemmed HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title_short HUMAN T LYMPHOCYTE "E" ROSETTE FUNCTION : I. A. Process Modulated by Intracellular Cyclic AMP
title_sort human t lymphocyte "e" rosette function : i. a. process modulated by intracellular cyclic amp
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139637/
https://www.ncbi.nlm.nih.gov/pubmed/4372291
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AT edgingtonthomass humantlymphocyteerosettefunctioniaprocessmodulatedbyintracellularcyclicamp

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