INFECTIOUS AGAMMAGLOBULINEMIA: TRANSMISSION OF IMMUNODEFICIENCY WITH GRAFTS OF AGAMMAGLOBULINEMIC CELLS

Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation. The immunodeficiency which develops in the recipients persists for life and is characterized by inabilit...

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Detalles Bibliográficos
Autores principales: Blaese, R. Michael, Weiden, Paul L., Koski, Irma, Dooley, Nancy
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139641/
https://www.ncbi.nlm.nih.gov/pubmed/4610075
Descripción
Sumario:Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation. The immunodeficiency which develops in the recipients persists for life and is characterized by inability to produce antibody and by progressive loss of detectable serum IgM and IgG.

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