IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE

Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for...

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Detalles Bibliográficos
Autores principales: Garvin, A. J., Spicer, S. S., Parmley, R. T., Munster, A. M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139657/
https://www.ncbi.nlm.nih.gov/pubmed/4132991
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author Garvin, A. J.
Spicer, S. S.
Parmley, R. T.
Munster, A. M.
author_facet Garvin, A. J.
Spicer, S. S.
Parmley, R. T.
Munster, A. M.
author_sort Garvin, A. J.
collection PubMed
description Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.
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spelling pubmed-21396572008-04-17 IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE Garvin, A. J. Spicer, S. S. Parmley, R. T. Munster, A. M. J Exp Med Article Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes. The Rockefeller University Press 1974-05-01 /pmc/articles/PMC2139657/ /pubmed/4132991 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Garvin, A. J.
Spicer, S. S.
Parmley, R. T.
Munster, A. M.
IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title_full IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title_fullStr IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title_full_unstemmed IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title_short IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
title_sort immunohistochemical demonstration of igg in reed-sternberg and other cells in hodgkin's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139657/
https://www.ncbi.nlm.nih.gov/pubmed/4132991
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AT spicerss immunohistochemicaldemonstrationofigginreedsternbergandothercellsinhodgkinsdisease
AT parmleyrt immunohistochemicaldemonstrationofigginreedsternbergandothercellsinhodgkinsdisease
AT munsteram immunohistochemicaldemonstrationofigginreedsternbergandothercellsinhodgkinsdisease

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