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ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES

The frequency of lymphocytes bearing complement receptors in the spleens of 2-wk old mice appears to be controlled by two independent genes. The presence of a "high" allele at either locus leads to intermediate or high frequency of CRL at 2 wk of age. One of the genes controlling complemen...

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Autores principales: Gelfand, Michael C., Sachs, David H., Lieberman, Rose, Paul, William E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139659/
https://www.ncbi.nlm.nih.gov/pubmed/4545163
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author Gelfand, Michael C.
Sachs, David H.
Lieberman, Rose
Paul, William E.
author_facet Gelfand, Michael C.
Sachs, David H.
Lieberman, Rose
Paul, William E.
author_sort Gelfand, Michael C.
collection PubMed
description The frequency of lymphocytes bearing complement receptors in the spleens of 2-wk old mice appears to be controlled by two independent genes. The presence of a "high" allele at either locus leads to intermediate or high frequency of CRL at 2 wk of age. One of the genes controlling complement receptor lymphocyte (CRL) frequency (CRL-1) is linked to the H-2 complex. Thus, in progeny of (AKR x DBA/2)F(1) x DBA/2, all mice with a low frequency of CRL at 2 wk of age are homozygous for the H-2 type of the low CRL parent (DBA/2). Furthermore, in the B10 series of congenic mice, CRL frequency at 2 wk of age is similar to the frequency in the donor of the H-2 region. Thus, C57BL/10, B10.BR, and B10-D2 mice are all of the low CRL type while B10.A mice are intermediate in CRL frequency at 2 wk. C57BR and DBA/2, the donors of the H-2 complex of the B10.BR and B10.D2, respectively, are of low CRL type while the A/WySn, the donor of the H-2 complex in the B10.A, is an intermediate CRL strain. Similarly in the A/WySn series of congenic mice, A.CA, A.SW, and A.BY are all low CRL strains while the A/WySn is intermediate. Studies of CRL frequency in mice with recombinant H-2 chromosomes (B10.A(2R), (4R), and (5R); B6/TL(+); and A/TL(-)) indicate that CRL-1 is to the right of the Ss-Slp genes and to the left of Tla.
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spelling pubmed-21396592008-04-17 ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES Gelfand, Michael C. Sachs, David H. Lieberman, Rose Paul, William E. J Exp Med Article The frequency of lymphocytes bearing complement receptors in the spleens of 2-wk old mice appears to be controlled by two independent genes. The presence of a "high" allele at either locus leads to intermediate or high frequency of CRL at 2 wk of age. One of the genes controlling complement receptor lymphocyte (CRL) frequency (CRL-1) is linked to the H-2 complex. Thus, in progeny of (AKR x DBA/2)F(1) x DBA/2, all mice with a low frequency of CRL at 2 wk of age are homozygous for the H-2 type of the low CRL parent (DBA/2). Furthermore, in the B10 series of congenic mice, CRL frequency at 2 wk of age is similar to the frequency in the donor of the H-2 region. Thus, C57BL/10, B10.BR, and B10-D2 mice are all of the low CRL type while B10.A mice are intermediate in CRL frequency at 2 wk. C57BR and DBA/2, the donors of the H-2 complex of the B10.BR and B10.D2, respectively, are of low CRL type while the A/WySn, the donor of the H-2 complex in the B10.A, is an intermediate CRL strain. Similarly in the A/WySn series of congenic mice, A.CA, A.SW, and A.BY are all low CRL strains while the A/WySn is intermediate. Studies of CRL frequency in mice with recombinant H-2 chromosomes (B10.A(2R), (4R), and (5R); B6/TL(+); and A/TL(-)) indicate that CRL-1 is to the right of the Ss-Slp genes and to the left of Tla. The Rockefeller University Press 1974-05-01 /pmc/articles/PMC2139659/ /pubmed/4545163 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gelfand, Michael C.
Sachs, David H.
Lieberman, Rose
Paul, William E.
ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title_full ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title_fullStr ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title_full_unstemmed ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title_short ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES
title_sort ontogeny of b lymphocytes : iii. h-2 linkage of a gene controlling the rate of appearance of complement receptor lymphocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139659/
https://www.ncbi.nlm.nih.gov/pubmed/4545163
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