INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at...

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Detalles Bibliográficos
Autores principales: Ioachim, Harry L., Keller, Steven E., Dorsett, Brent H., Pearse, Antonia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139688/
https://www.ncbi.nlm.nih.gov/pubmed/4208416
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author Ioachim, Harry L.
Keller, Steven E.
Dorsett, Brent H.
Pearse, Antonia
author_facet Ioachim, Harry L.
Keller, Steven E.
Dorsett, Brent H.
Pearse, Antonia
author_sort Ioachim, Harry L.
collection PubMed
description Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis.
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spelling pubmed-21396882008-04-17 INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA Ioachim, Harry L. Keller, Steven E. Dorsett, Brent H. Pearse, Antonia J Exp Med Article Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis. The Rockefeller University Press 1974-06-01 /pmc/articles/PMC2139688/ /pubmed/4208416 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ioachim, Harry L.
Keller, Steven E.
Dorsett, Brent H.
Pearse, Antonia
INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title_full INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title_fullStr INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title_full_unstemmed INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title_short INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA
title_sort induction of partial immunologic tolerance in rats and progressive loss of cellular antigenicity in gross virus lymphoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139688/
https://www.ncbi.nlm.nih.gov/pubmed/4208416
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AT dorsettbrenth inductionofpartialimmunologictoleranceinratsandprogressivelossofcellularantigenicityingrossviruslymphoma
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