RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE

These studies demonstrate that mice tolerant to human gamma globulin (HGG) regain their ability to make antibody to HGG after parabiosis to normal mice. This can be demonstrated by enumeration of PFC in the spleens of both the normal and tolerant partners. Hemagglutinin titers of normal-tolerant par...

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Detalles Bibliográficos
Autores principales: Zolla, Susan, Naor, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139713/
https://www.ncbi.nlm.nih.gov/pubmed/4138703
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author Zolla, Susan
Naor, David
author_facet Zolla, Susan
Naor, David
author_sort Zolla, Susan
collection PubMed
description These studies demonstrate that mice tolerant to human gamma globulin (HGG) regain their ability to make antibody to HGG after parabiosis to normal mice. This can be demonstrated by enumeration of PFC in the spleens of both the normal and tolerant partners. Hemagglutinin titers of normal-tolerant parabionts, however, are exceptionally low; serum antibody appears to be neutralized by circulating HGG present originally in the serum of the tolerant partner. These data support the hypothesis that tolerance to HGG in mice is a "defective" state due to the absence of cells capable of responding to this antigen.
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spelling pubmed-21397132008-04-17 RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE Zolla, Susan Naor, David J Exp Med Brief Definitive Reports These studies demonstrate that mice tolerant to human gamma globulin (HGG) regain their ability to make antibody to HGG after parabiosis to normal mice. This can be demonstrated by enumeration of PFC in the spleens of both the normal and tolerant partners. Hemagglutinin titers of normal-tolerant parabionts, however, are exceptionally low; serum antibody appears to be neutralized by circulating HGG present originally in the serum of the tolerant partner. These data support the hypothesis that tolerance to HGG in mice is a "defective" state due to the absence of cells capable of responding to this antigen. The Rockefeller University Press 1974-10-31 /pmc/articles/PMC2139713/ /pubmed/4138703 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Reports
Zolla, Susan
Naor, David
RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title_full RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title_fullStr RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title_full_unstemmed RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title_short RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
title_sort restoration of immune competence in tolerant mice by parabiosis to normal mice
topic Brief Definitive Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139713/
https://www.ncbi.nlm.nih.gov/pubmed/4138703
work_keys_str_mv AT zollasusan restorationofimmunecompetenceintolerantmicebyparabiosistonormalmice
AT naordavid restorationofimmunecompetenceintolerantmicebyparabiosistonormalmice

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