SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome

Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated t...

Descripción completa

Detalles Bibliográficos
Autores principales: Croce, Carlo M., Koprowski, Hilary
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139719/
https://www.ncbi.nlm.nih.gov/pubmed/4371646
_version_ 1782143862050914304
author Croce, Carlo M.
Koprowski, Hilary
author_facet Croce, Carlo M.
Koprowski, Hilary
author_sort Croce, Carlo M.
collection PubMed
description Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated that the hybridization of mouse nondividing cells with human cancer cells could permit the identification of the human "oncogenic" chromosome(s) present in human cancer cells, since such chromosome(s) should be retained by the totality of the mouse-human hybrid cells.
format Text
id pubmed-2139719
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21397192008-04-17 SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome Croce, Carlo M. Koprowski, Hilary J Exp Med Article Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated that the hybridization of mouse nondividing cells with human cancer cells could permit the identification of the human "oncogenic" chromosome(s) present in human cancer cells, since such chromosome(s) should be retained by the totality of the mouse-human hybrid cells. The Rockefeller University Press 1974-10-31 /pmc/articles/PMC2139719/ /pubmed/4371646 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Croce, Carlo M.
Koprowski, Hilary
SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title_full SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title_fullStr SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title_full_unstemmed SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title_short SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS : I. Positive Control of the Transformed Phenotype by the Human Chromosome 7 Carrying the SV40 Genome
title_sort somatic cell hybrids between mouse peritoneal macrophages and sv40-transformed human cells : i. positive control of the transformed phenotype by the human chromosome 7 carrying the sv40 genome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139719/
https://www.ncbi.nlm.nih.gov/pubmed/4371646
work_keys_str_mv AT crocecarlom somaticcellhybridsbetweenmouseperitonealmacrophagesandsv40transformedhumancellsipositivecontrolofthetransformedphenotypebythehumanchromosome7carryingthesv40genome
AT koprowskihilary somaticcellhybridsbetweenmouseperitonealmacrophagesandsv40transformedhumancellsipositivecontrolofthetransformedphenotypebythehumanchromosome7carryingthesv40genome

Ejemplares similares