I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)

Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region,...

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Detalles Bibliográficos
Autores principales: Lonai, Peter, McDevitt, Hugh O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139724/
https://www.ncbi.nlm.nih.gov/pubmed/4153771
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author Lonai, Peter
McDevitt, Hugh O.
author_facet Lonai, Peter
McDevitt, Hugh O.
author_sort Lonai, Peter
collection PubMed
description Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.
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spelling pubmed-21397242008-04-17 I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR) Lonai, Peter McDevitt, Hugh O. J Exp Med Article Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells. The Rockefeller University Press 1974-10-31 /pmc/articles/PMC2139724/ /pubmed/4153771 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lonai, Peter
McDevitt, Hugh O.
I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title_full I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title_fullStr I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title_full_unstemmed I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title_short I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)
title_sort i-region genes are expressed on t and b lymphocytes : studies of the mixed lymphocyte reaction (mlr)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139724/
https://www.ncbi.nlm.nih.gov/pubmed/4153771
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