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Regulated Membrane Localization of Tiam1, Mediated by the NH(2)-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH(2)-terminal Kinase Activation

Rho-like GTPases, including Cdc42, Rac, and Rho, regulate signaling pathways that control actin cytoskeletal structures and transcriptional activation. The Tiam1 gene encodes an activator of Rac1, and similarly to constitutively activated (V12)Rac1, overexpression of Tiam1 in fibroblasts induces the...

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Detalles Bibliográficos
Autores principales:	Michiels, Frits, Stam, Jord C., Hordijk, Peter L., van der Kammen, Rob A., Stalle, Lisette Ruuls-Van, Feltkamp, Constance A., Collard, John G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139766/ https://www.ncbi.nlm.nih.gov/pubmed/9128250

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