Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

Members of the TGF-β superfamily are important regulators of skeletal development. TGF-βs signal through heteromeric type I and type II receptor serine/threonine kinases. When over-expressed, a cytoplasmically truncated type II receptor can compete with the endogenous receptors for complex formation...

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Detalles Bibliográficos
Autores principales: Serra, Rosa, Johnson, Mahlon, Filvaroff, Ellen H., LaBorde, James, Sheehan, Daniel M., Derynck, Rik, Moses, Harold L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139797/
https://www.ncbi.nlm.nih.gov/pubmed/9334355

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