Point Mutations in Human β Cardiac Myosin Heavy Chain Have Differential Effects on Sarcomeric Structure and Assembly: An ATP Binding Site Change Disrupts Both Thick and Thin Filaments, Whereas Hypertrophic Cardiomyopathy Mutations Display Normal Assembly

Hypertrophic cardiomyopathy is a human heart disease characterized by increased ventricular mass, focal areas of fibrosis, myocyte, and myofibrillar disorganization. This genetically dominant disease can be caused by mutations in any one of several contractile proteins, including β cardiac myosin he...

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Detalles Bibliográficos
Autores principales: Becker, K. David, Gottshall, Kim R., Hickey, Reed, Perriard, Jean-Claude, Chien, Kenneth R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139848/
https://www.ncbi.nlm.nih.gov/pubmed/9105042

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