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Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics

The emerging domain of epigenetics in molecular medicine finds application for a variety of patient populations. Here, we present fundamental neuroendocrine immune evidence obtained in patients with senile dementia of the Alzheimer's type (sDAT), and discuss the implications of these data from...

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Autores principales: Chiappelli, Francesco, Prolo, Paolo, D. Cajulis, Kristine, Angeli, Alberto, Dovio, Andrea, Perotti, Paola, Pautasso, Marisa, Luisa Sartori, Maria, Saba, Laura, Mussino, Stefano, Fraccalini, Thomas, Fanto, Fausto, Manfrini, Ercolano, Mocellini, Cristina, Gabriella Rosso, Maria, Grasso, Enzo
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139995/
https://www.ncbi.nlm.nih.gov/pubmed/18084641
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author Chiappelli, Francesco
Prolo, Paolo
D. Cajulis, Kristine
Angeli, Alberto
Dovio, Andrea
Perotti, Paola
Pautasso, Marisa
Luisa Sartori, Maria
Saba, Laura
Mussino, Stefano
Fraccalini, Thomas
Fanto, Fausto
Manfrini, Ercolano
Mocellini, Cristina
Gabriella Rosso, Maria
Grasso, Enzo
author_facet Chiappelli, Francesco
Prolo, Paolo
D. Cajulis, Kristine
Angeli, Alberto
Dovio, Andrea
Perotti, Paola
Pautasso, Marisa
Luisa Sartori, Maria
Saba, Laura
Mussino, Stefano
Fraccalini, Thomas
Fanto, Fausto
Manfrini, Ercolano
Mocellini, Cristina
Gabriella Rosso, Maria
Grasso, Enzo
author_sort Chiappelli, Francesco
collection PubMed
description The emerging domain of epigenetics in molecular medicine finds application for a variety of patient populations. Here, we present fundamental neuroendocrine immune evidence obtained in patients with senile dementia of the Alzheimer's type (sDAT), and discuss the implications of these data from the viewpoint of translational epigenetics of Alzheimer's disease. We followed 18 subjects with mild sDAT treated with acetylcholinesterase inhibitors, and 10 control subjects matched for age in a repeated measure design every six months for 18 months. We monitored psychosocial profile (Mini-Mental State Examination, Functional Assessment Staging, Independence in Activities of Daily Living, Depression, Profile of Moods States) in parallel to immunophenotypic parameters of T cell subpopulations by flow cytometry. Based on change in the mini-mental state score at entry and at 18 months, patients with sDAT were assigned to a “fast progression” (delta greater than 2 points) or to a “slow progression” group (delta less than or equal to 2 points). The change in circulating activated T cells (CD3+Dr+) with time in patients with sDAT was significantly inversely correlated with the change in time in natural killer (NK) cytotoxic activity to cortisol modulation in these patients, which was greater in patients with fast progression, compared to slow progression sDAT. These data indicate underlying neuroendocrine immune processes during progression of sDAT. Our observations suggest that psychoimmune measures such as those we have monitored in this study provide relevant information about the evolving physiological modulation in patients with sDAT during progression of Alzheimer's disease, and point to new or improved translational epigenetic treatment interventions.
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spelling pubmed-21399952007-12-14 Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics Chiappelli, Francesco Prolo, Paolo D. Cajulis, Kristine Angeli, Alberto Dovio, Andrea Perotti, Paola Pautasso, Marisa Luisa Sartori, Maria Saba, Laura Mussino, Stefano Fraccalini, Thomas Fanto, Fausto Manfrini, Ercolano Mocellini, Cristina Gabriella Rosso, Maria Grasso, Enzo Bioinformation Hypothesis The emerging domain of epigenetics in molecular medicine finds application for a variety of patient populations. Here, we present fundamental neuroendocrine immune evidence obtained in patients with senile dementia of the Alzheimer's type (sDAT), and discuss the implications of these data from the viewpoint of translational epigenetics of Alzheimer's disease. We followed 18 subjects with mild sDAT treated with acetylcholinesterase inhibitors, and 10 control subjects matched for age in a repeated measure design every six months for 18 months. We monitored psychosocial profile (Mini-Mental State Examination, Functional Assessment Staging, Independence in Activities of Daily Living, Depression, Profile of Moods States) in parallel to immunophenotypic parameters of T cell subpopulations by flow cytometry. Based on change in the mini-mental state score at entry and at 18 months, patients with sDAT were assigned to a “fast progression” (delta greater than 2 points) or to a “slow progression” group (delta less than or equal to 2 points). The change in circulating activated T cells (CD3+Dr+) with time in patients with sDAT was significantly inversely correlated with the change in time in natural killer (NK) cytotoxic activity to cortisol modulation in these patients, which was greater in patients with fast progression, compared to slow progression sDAT. These data indicate underlying neuroendocrine immune processes during progression of sDAT. Our observations suggest that psychoimmune measures such as those we have monitored in this study provide relevant information about the evolving physiological modulation in patients with sDAT during progression of Alzheimer's disease, and point to new or improved translational epigenetic treatment interventions. Biomedical Informatics Publishing Group 2007-05-20 /pmc/articles/PMC2139995/ /pubmed/18084641 Text en © 2007 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Chiappelli, Francesco
Prolo, Paolo
D. Cajulis, Kristine
Angeli, Alberto
Dovio, Andrea
Perotti, Paola
Pautasso, Marisa
Luisa Sartori, Maria
Saba, Laura
Mussino, Stefano
Fraccalini, Thomas
Fanto, Fausto
Manfrini, Ercolano
Mocellini, Cristina
Gabriella Rosso, Maria
Grasso, Enzo
Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title_full Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title_fullStr Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title_full_unstemmed Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title_short Neuroendocrine immunity in patients with Alzheimer's disease: toward translational epigenetics
title_sort neuroendocrine immunity in patients with alzheimer's disease: toward translational epigenetics
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139995/
https://www.ncbi.nlm.nih.gov/pubmed/18084641
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