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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

The conjunctive presence of mechanical stress and active transforming growth factor β1 (TGF-β1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts and conditions that permit tension modulation on th...

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Detalles Bibliográficos
Autores principales:	Wipff, Pierre-Jean, Rifkin, Daniel B., Meister, Jean-Jacques, Hinz, Boris
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140013/ https://www.ncbi.nlm.nih.gov/pubmed/18086923 http://dx.doi.org/10.1083/jcb.200704042

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