MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis

Increasing evidence suggests that neurotoxicity of secreted superoxide dismutase 1 (SOD1) mutants is associated with amyotrophic lateral sclerosis (ALS). We show here that mutant SOD1 protein activates microglia via a myeloid differentiation factor 88 (MyD88)–dependent pathway. This inflammatory res...

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Detalles Bibliográficos
Autores principales: Kang, Jihong, Rivest, Serge
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140021/
https://www.ncbi.nlm.nih.gov/pubmed/18086918
http://dx.doi.org/10.1083/jcb.200705046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140021/
https://www.ncbi.nlm.nih.gov/pubmed/18086918
http://dx.doi.org/10.1083/jcb.200705046

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