THE STABILITY OF BACTERIAL SUSPENSIONS : IV. THE COMBINATION OF ANTIGEN AND ANTIBODY AT DIFFERENT HYDROGEN ION CONCENTRATIONS.

1. The amount of immune body required to agglutinate a suspension of Bacillus typhosus increases in direct proportion to the concentration of the suspension. 2. The amount of immune body combined with the organisms is constant from pH 9 to pH 3.7. Below the latter value the amount in combination is...

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Detalles Bibliográficos
Autores principales: De Kruif, Paul H., Northrop, John H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1922
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140564/
https://www.ncbi.nlm.nih.gov/pubmed/19871982
Descripción
Sumario:1. The amount of immune body required to agglutinate a suspension of Bacillus typhosus increases in direct proportion to the concentration of the suspension. 2. The amount of immune body combined with the organisms is constant from pH 9 to pH 3.7. Below the latter value the amount in combination is decreased. 3. The addition of immune serum to a suspension of Bacillus typhosus at a pH of 2,5 increases the positive charge of the organisms. These results are contradictory to the idea that the combination is caused by a difference in the sign of the charge carried by the immune body and the organism. They agree with the assumption that the immune body forms a film on the surface of the organism and that the effect on the charge is the result of this film.

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