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SOME PHYSIOLOGICAL ACTIONS OF CYANIDES

1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity...

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Detalles Bibliográficos
Autor principal: Bodine, Joseph Hall
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1924
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140659/
https://www.ncbi.nlm.nih.gov/pubmed/19872122
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author Bodine, Joseph Hall
author_facet Bodine, Joseph Hall
author_sort Bodine, Joseph Hall
collection PubMed
description 1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity the presence of a considerable amount of free HCN molecules in the presence of their salts; (c) to specific effects occasioned by its chemical activity. 2. The order of resistance of various protozoans to HCN resembles that of the same protozoa to CO(2) and to H(2)S, but is the reverse of their resistance to mineral acids. 3. HCN in acid, neutral, or slightly alkaline media produces intracellular acidity because of the rapid penetration of HCN molecules into the cell. 4. HCN acts specifically on certain species of protozoa, the order of resistance of Paramecia being Paramecium caudatum > Paramecium mullimicronucleatum > Paramecium aurelia > Paramecium bursaria.
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spelling pubmed-21406592008-04-23 SOME PHYSIOLOGICAL ACTIONS OF CYANIDES Bodine, Joseph Hall J Gen Physiol Article 1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity the presence of a considerable amount of free HCN molecules in the presence of their salts; (c) to specific effects occasioned by its chemical activity. 2. The order of resistance of various protozoans to HCN resembles that of the same protozoa to CO(2) and to H(2)S, but is the reverse of their resistance to mineral acids. 3. HCN in acid, neutral, or slightly alkaline media produces intracellular acidity because of the rapid penetration of HCN molecules into the cell. 4. HCN acts specifically on certain species of protozoa, the order of resistance of Paramecia being Paramecium caudatum > Paramecium mullimicronucleatum > Paramecium aurelia > Paramecium bursaria. The Rockefeller University Press 1924-09-20 /pmc/articles/PMC2140659/ /pubmed/19872122 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bodine, Joseph Hall
SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title_full SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title_fullStr SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title_full_unstemmed SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title_short SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
title_sort some physiological actions of cyanides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140659/
https://www.ncbi.nlm.nih.gov/pubmed/19872122
work_keys_str_mv AT bodinejosephhall somephysiologicalactionsofcyanides