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SOME PHYSIOLOGICAL ACTIONS OF CYANIDES
1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1924
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140659/ https://www.ncbi.nlm.nih.gov/pubmed/19872122 |
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author | Bodine, Joseph Hall |
author_facet | Bodine, Joseph Hall |
author_sort | Bodine, Joseph Hall |
collection | PubMed |
description | 1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity the presence of a considerable amount of free HCN molecules in the presence of their salts; (c) to specific effects occasioned by its chemical activity. 2. The order of resistance of various protozoans to HCN resembles that of the same protozoa to CO(2) and to H(2)S, but is the reverse of their resistance to mineral acids. 3. HCN in acid, neutral, or slightly alkaline media produces intracellular acidity because of the rapid penetration of HCN molecules into the cell. 4. HCN acts specifically on certain species of protozoa, the order of resistance of Paramecia being Paramecium caudatum > Paramecium mullimicronucleatum > Paramecium aurelia > Paramecium bursaria. |
format | Text |
id | pubmed-2140659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1924 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21406592008-04-23 SOME PHYSIOLOGICAL ACTIONS OF CYANIDES Bodine, Joseph Hall J Gen Physiol Article 1. The physiological actions of HCN and its salts appear to be due (a) to the ease with which HCN molecules penetrate living cells and then ionizing, exert their influence by means of H ions and CN ions; (b) to the weakness of HCN as an acid, which permits at neutrality or at even slight alkalinity the presence of a considerable amount of free HCN molecules in the presence of their salts; (c) to specific effects occasioned by its chemical activity. 2. The order of resistance of various protozoans to HCN resembles that of the same protozoa to CO(2) and to H(2)S, but is the reverse of their resistance to mineral acids. 3. HCN in acid, neutral, or slightly alkaline media produces intracellular acidity because of the rapid penetration of HCN molecules into the cell. 4. HCN acts specifically on certain species of protozoa, the order of resistance of Paramecia being Paramecium caudatum > Paramecium mullimicronucleatum > Paramecium aurelia > Paramecium bursaria. The Rockefeller University Press 1924-09-20 /pmc/articles/PMC2140659/ /pubmed/19872122 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Bodine, Joseph Hall SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title | SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title_full | SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title_fullStr | SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title_full_unstemmed | SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title_short | SOME PHYSIOLOGICAL ACTIONS OF CYANIDES |
title_sort | some physiological actions of cyanides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140659/ https://www.ncbi.nlm.nih.gov/pubmed/19872122 |
work_keys_str_mv | AT bodinejosephhall somephysiologicalactionsofcyanides |