THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.

The rate of digestion of concentrated casein solutions by low concentrations of trypsin at 0° has been followed. Under these conditions the enzyme is inhibited by the product of the reaction and under certain conditions this effect should lead to Schütz's rule, i.e. the amount of hydrolysis sho...

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Detalles Bibliográficos
Autor principal: Northrop, John H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1924
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140682/
https://www.ncbi.nlm.nih.gov/pubmed/19872112
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author Northrop, John H.
author_facet Northrop, John H.
author_sort Northrop, John H.
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description The rate of digestion of concentrated casein solutions by low concentrations of trypsin at 0° has been followed. Under these conditions the enzyme is inhibited by the product of the reaction and under certain conditions this effect should lead to Schütz's rule, i.e. the amount of hydrolysis should be proportional to the square root of the product of the time into the enzyme concentration. This is the result obtained. Both Schütz's rule and Arrhenius' equation fail to hold accurately owing to the incorrect relation assumed to hold between the rate of hydrolysis and the substrate concentration.
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spelling pubmed-21406822008-04-23 THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE. Northrop, John H. J Gen Physiol Article The rate of digestion of concentrated casein solutions by low concentrations of trypsin at 0° has been followed. Under these conditions the enzyme is inhibited by the product of the reaction and under certain conditions this effect should lead to Schütz's rule, i.e. the amount of hydrolysis should be proportional to the square root of the product of the time into the enzyme concentration. This is the result obtained. Both Schütz's rule and Arrhenius' equation fail to hold accurately owing to the incorrect relation assumed to hold between the rate of hydrolysis and the substrate concentration. The Rockefeller University Press 1924-07-20 /pmc/articles/PMC2140682/ /pubmed/19872112 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Northrop, John H.
THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title_full THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title_fullStr THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title_full_unstemmed THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title_short THE KINETICS OF TRYPSIN DIGESTION : V. SCHUTZ'S RULE.
title_sort kinetics of trypsin digestion : v. schutz's rule.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140682/
https://www.ncbi.nlm.nih.gov/pubmed/19872112
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