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THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS

Ashby's work on the effects of KCl and NaCl on the resistance to hypotonic hemolysis of K(•)-rich and K(•)-poor erythrocytes has been repeated with great attention to purity of materials and refinement of technique. The results fail to agree with those of Ashby. 1. KCl produces greater loss in...

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Detalles Bibliográficos
Autor principal: Brooks, S. C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1925
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140744/
https://www.ncbi.nlm.nih.gov/pubmed/19872161
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author Brooks, S. C.
author_facet Brooks, S. C.
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description Ashby's work on the effects of KCl and NaCl on the resistance to hypotonic hemolysis of K(•)-rich and K(•)-poor erythrocytes has been repeated with great attention to purity of materials and refinement of technique. The results fail to agree with those of Ashby. 1. KCl produces greater loss in resistance to hypotonic hemolysis than does NaCl, irrespective of the species of the animal from which the cells are taken. 2. While cases of an increase in resistance have been encountered in my experiments, they are either very slight, or else the particular determination is subject to very great uncertainty. The great increases in resistance found by Ashby are not even approached in any of the present series of experiments. 3. Ashby's generalization that KCl and NaCl have opposite effects on red blood cells, and that the sense of these effects depends on whether the cell is K(•)-rich or K(•)-poor is not substantiated.
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spelling pubmed-21407442008-04-23 THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS Brooks, S. C. J Gen Physiol Article Ashby's work on the effects of KCl and NaCl on the resistance to hypotonic hemolysis of K(•)-rich and K(•)-poor erythrocytes has been repeated with great attention to purity of materials and refinement of technique. The results fail to agree with those of Ashby. 1. KCl produces greater loss in resistance to hypotonic hemolysis than does NaCl, irrespective of the species of the animal from which the cells are taken. 2. While cases of an increase in resistance have been encountered in my experiments, they are either very slight, or else the particular determination is subject to very great uncertainty. The great increases in resistance found by Ashby are not even approached in any of the present series of experiments. 3. Ashby's generalization that KCl and NaCl have opposite effects on red blood cells, and that the sense of these effects depends on whether the cell is K(•)-rich or K(•)-poor is not substantiated. The Rockefeller University Press 1925-05-20 /pmc/articles/PMC2140744/ /pubmed/19872161 Text en Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Brooks, S. C.
THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title_full THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title_fullStr THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title_full_unstemmed THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title_short THE MECHANISM OF CHANGE IN RESISTANCE OF ERYTHROCYTES TO HYPOTONIC SALT SOLUTIONS
title_sort mechanism of change in resistance of erythrocytes to hypotonic salt solutions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140744/
https://www.ncbi.nlm.nih.gov/pubmed/19872161
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