ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS

Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of...

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Detalles Bibliográficos
Autores principales: McCutcheon, Morton, Mudd, Stuart, Strumia, Max, Lucké, Balduin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1930
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141072/
https://www.ncbi.nlm.nih.gov/pubmed/19872556
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author McCutcheon, Morton
Mudd, Stuart
Strumia, Max
Lucké, Balduin
author_facet McCutcheon, Morton
Mudd, Stuart
Strumia, Max
Lucké, Balduin
author_sort McCutcheon, Morton
collection PubMed
description Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of the same immune sera have been isoelectric at pH 5.1 to 5.2. The combination of antigen with antibody depends of course upon specific affinities; the surface properties of the sensitized antigen, agglutination and phagocytosis depend primarily upon the properties of the sensitizing serum substances combined with and deposited on the antigen surface.
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spelling pubmed-21410722008-04-23 ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS McCutcheon, Morton Mudd, Stuart Strumia, Max Lucké, Balduin J Gen Physiol Article Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of the same immune sera have been isoelectric at pH 5.1 to 5.2. The combination of antigen with antibody depends of course upon specific affinities; the surface properties of the sensitized antigen, agglutination and phagocytosis depend primarily upon the properties of the sensitizing serum substances combined with and deposited on the antigen surface. The Rockefeller University Press 1930-07-20 /pmc/articles/PMC2141072/ /pubmed/19872556 Text en Copyright © Copyright, 1930, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McCutcheon, Morton
Mudd, Stuart
Strumia, Max
Lucké, Balduin
ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title_full ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title_fullStr ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title_full_unstemmed ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title_short ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS
title_sort on the mechanism of opsonin and bacteriotropin action : iv. the isoelectric points of certain sensitized antigens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141072/
https://www.ncbi.nlm.nih.gov/pubmed/19872556
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