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ON THE MEASURE OF EXCITABILITY

Recent time-intensity data by Rushton (1932) on the sciatic nerve of the frog are shown to provide additional support to the writer's suggestion (1932, a) that integrals of the equation See PDF for Equation where V is the applied voltage, p is the local excitatory process and K and k are consta...

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Detalles Bibliográficos
Autor principal: Blair, H. A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1932
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141206/
https://www.ncbi.nlm.nih.gov/pubmed/19872696
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author Blair, H. A.
author_facet Blair, H. A.
author_sort Blair, H. A.
collection PubMed
description Recent time-intensity data by Rushton (1932) on the sciatic nerve of the frog are shown to provide additional support to the writer's suggestion (1932, a) that integrals of the equation See PDF for Equation where V is the applied voltage, p is the local excitatory process and K and k are constants adequately represent the just effective direct current stimuli when the threshold value of p is made a linear function of the voltage of the form h ± α V where h and α are constants. The measurement of excitability is discussed and it is shown that the criteria for "true" measurements are not likely to be found by the agreement of the data with canonical time-intensity functions as suggested by Lapicque (1931) but rather in the establishing of standard experimental conditions. These conditions may permit the use of chronaxie as a measure of excitability, but it seems more likely that the constant k of the above equation will have to be adopted. There is sufficient evidence to cast considerable doubt on the validity of any conclusions drawn from the existing measurements of chronaxie although those derived through a particular technique may be valid. The problem requires a thorough experimental investigation in terms of integrals of the above equation.
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spelling pubmed-21412062008-04-23 ON THE MEASURE OF EXCITABILITY Blair, H. A. J Gen Physiol Article Recent time-intensity data by Rushton (1932) on the sciatic nerve of the frog are shown to provide additional support to the writer's suggestion (1932, a) that integrals of the equation See PDF for Equation where V is the applied voltage, p is the local excitatory process and K and k are constants adequately represent the just effective direct current stimuli when the threshold value of p is made a linear function of the voltage of the form h ± α V where h and α are constants. The measurement of excitability is discussed and it is shown that the criteria for "true" measurements are not likely to be found by the agreement of the data with canonical time-intensity functions as suggested by Lapicque (1931) but rather in the establishing of standard experimental conditions. These conditions may permit the use of chronaxie as a measure of excitability, but it seems more likely that the constant k of the above equation will have to be adopted. There is sufficient evidence to cast considerable doubt on the validity of any conclusions drawn from the existing measurements of chronaxie although those derived through a particular technique may be valid. The problem requires a thorough experimental investigation in terms of integrals of the above equation. The Rockefeller University Press 1932-11-20 /pmc/articles/PMC2141206/ /pubmed/19872696 Text en Copyright © Copyright, 1932, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Blair, H. A.
ON THE MEASURE OF EXCITABILITY
title ON THE MEASURE OF EXCITABILITY
title_full ON THE MEASURE OF EXCITABILITY
title_fullStr ON THE MEASURE OF EXCITABILITY
title_full_unstemmed ON THE MEASURE OF EXCITABILITY
title_short ON THE MEASURE OF EXCITABILITY
title_sort on the measure of excitability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141206/
https://www.ncbi.nlm.nih.gov/pubmed/19872696
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