THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM

The potentiometric method was applied to the study of the influence of cyanide and of hydroxyl ion on methemoglobin. Both of these ions appear to combine with the iron of the methemoglobin molecule and reduce its oxidant activity. From the magnitude of the effect produced by cyanide and by variation...

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Detalles Bibliográficos
Autor principal: Barnard, Robert D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1933
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141230/
https://www.ncbi.nlm.nih.gov/pubmed/19872729
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author Barnard, Robert D.
author_facet Barnard, Robert D.
author_sort Barnard, Robert D.
collection PubMed
description The potentiometric method was applied to the study of the influence of cyanide and of hydroxyl ion on methemoglobin. Both of these ions appear to combine with the iron of the methemoglobin molecule and reduce its oxidant activity. From the magnitude of the effect produced by cyanide and by variation in pH on the oxidation-reduction potential of the methemoglobin-hemoglobin system, it is concluded that cyanmethemoglobin and alkaline methemoglobin are undissociated ferric compounds, the first with cyanide and the second with hydroxyl. Electronic formulas, based on the electrical properties of the hemoglobin derivatives, are suggested.
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spelling pubmed-21412302008-04-23 THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM Barnard, Robert D. J Gen Physiol Article The potentiometric method was applied to the study of the influence of cyanide and of hydroxyl ion on methemoglobin. Both of these ions appear to combine with the iron of the methemoglobin molecule and reduce its oxidant activity. From the magnitude of the effect produced by cyanide and by variation in pH on the oxidation-reduction potential of the methemoglobin-hemoglobin system, it is concluded that cyanmethemoglobin and alkaline methemoglobin are undissociated ferric compounds, the first with cyanide and the second with hydroxyl. Electronic formulas, based on the electrical properties of the hemoglobin derivatives, are suggested. The Rockefeller University Press 1933-03-20 /pmc/articles/PMC2141230/ /pubmed/19872729 Text en Copyright © Copyright, 1933, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Barnard, Robert D.
THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title_full THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title_fullStr THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title_full_unstemmed THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title_short THE EFFECT OF CYANIDE AND OF VARIATION IN ALKALINITY ON THE OXIDATION-REDUCTION POTENTIAL OF THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM
title_sort effect of cyanide and of variation in alkalinity on the oxidation-reduction potential of the hemoglobin-methemoglobin system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141230/
https://www.ncbi.nlm.nih.gov/pubmed/19872729
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