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THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE
1. The kinetics of the reaction which takes place between glycine and iodoacetic acid was studied by means of the polarographic method. 2. On the basis of kinetic equations, evidence was obtained that (a) The reaction proceeds in two steps in which the hydrogens of the amino group are consecutively...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1936
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141468/ https://www.ncbi.nlm.nih.gov/pubmed/19872966 |
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author | Brdička, R. |
author_facet | Brdička, R. |
author_sort | Brdička, R. |
collection | PubMed |
description | 1. The kinetics of the reaction which takes place between glycine and iodoacetic acid was studied by means of the polarographic method. 2. On the basis of kinetic equations, evidence was obtained that (a) The reaction proceeds in two steps in which the hydrogens of the amino group are consecutively replaced by the acetyl radicals, the velocity constants being in the ratio 2:1. (b) Only the anionic form of glycine is able to react since the velocity constants at any pH are proportional to the concentration of glycine anion. (c) The reaction is of the ionic type, showing a positive salt catalysis, which, according to Brönsted's hypothesis, involves the primary and the secondary salt effects. 3. The fact that only the glycine anion is able to react was explained as being due to the existence of an unbonded pair of electrons on the nitrogen in the NH(2) group. The NH(3) (+) group, however, in which these electrons are shared by H(+), must, therefore, be inactive. |
format | Text |
id | pubmed-2141468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1936 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21414682008-04-23 THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE Brdička, R. J Gen Physiol Article 1. The kinetics of the reaction which takes place between glycine and iodoacetic acid was studied by means of the polarographic method. 2. On the basis of kinetic equations, evidence was obtained that (a) The reaction proceeds in two steps in which the hydrogens of the amino group are consecutively replaced by the acetyl radicals, the velocity constants being in the ratio 2:1. (b) Only the anionic form of glycine is able to react since the velocity constants at any pH are proportional to the concentration of glycine anion. (c) The reaction is of the ionic type, showing a positive salt catalysis, which, according to Brönsted's hypothesis, involves the primary and the secondary salt effects. 3. The fact that only the glycine anion is able to react was explained as being due to the existence of an unbonded pair of electrons on the nitrogen in the NH(2) group. The NH(3) (+) group, however, in which these electrons are shared by H(+), must, therefore, be inactive. The Rockefeller University Press 1936-05-20 /pmc/articles/PMC2141468/ /pubmed/19872966 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Brdička, R. THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title | THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title_full | THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title_fullStr | THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title_full_unstemmed | THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title_short | THE KINETICS OF THE REACTION WHICH TAKES PLACE BETWEEN IODOACETIC ACID AND GLYCINE |
title_sort | kinetics of the reaction which takes place between iodoacetic acid and glycine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141468/ https://www.ncbi.nlm.nih.gov/pubmed/19872966 |
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