IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN

1. Alkali (pH 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. Similarly treated pepsins from the rabbit, chicken, and shark do not. 2. Pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous...

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Detalles Bibliográficos
Autores principales: Seastone, C. V., Herriott, R. M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1937
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141530/
https://www.ncbi.nlm.nih.gov/pubmed/19873029
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author Seastone, C. V.
Herriott, R. M.
author_facet Seastone, C. V.
Herriott, R. M.
author_sort Seastone, C. V.
collection PubMed
description 1. Alkali (pH 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. Similarly treated pepsins from the rabbit, chicken, and shark do not. 2. Pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. Pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, nor with the serum proteins from the homologous species. Positive reactions between activated pepsinogen and pepsinogen antiserum have been observed. It was possible to remove the reacting material from either the pepsinogen or the activated pepsinogen mixture. 4. Antisera made with serum proteins do not react with the homologous pepsin or pepsinogen.
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spelling pubmed-21415302008-04-23 IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN Seastone, C. V. Herriott, R. M. J Gen Physiol Article 1. Alkali (pH 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. Similarly treated pepsins from the rabbit, chicken, and shark do not. 2. Pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. Pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, nor with the serum proteins from the homologous species. Positive reactions between activated pepsinogen and pepsinogen antiserum have been observed. It was possible to remove the reacting material from either the pepsinogen or the activated pepsinogen mixture. 4. Antisera made with serum proteins do not react with the homologous pepsin or pepsinogen. The Rockefeller University Press 1937-07-20 /pmc/articles/PMC2141530/ /pubmed/19873029 Text en Copyright © Copyright, 1937, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Seastone, C. V.
Herriott, R. M.
IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title_full IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title_fullStr IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title_full_unstemmed IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title_short IMMUNOLOGICAL STUDIES ON PEPSIN AND PEPSINOGEN
title_sort immunological studies on pepsin and pepsinogen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141530/
https://www.ncbi.nlm.nih.gov/pubmed/19873029
work_keys_str_mv AT seastonecv immunologicalstudiesonpepsinandpepsinogen
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