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The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity
Cadherins are transmembrane glycoproteins involved in Ca(2+)-dependent cell–cell adhesion. Deletion of the COOH-terminal residues of the E-cadherin cytoplasmic domain has been shown to abolish its cell adhesive activity, which has been ascribed to the failure of the deletion mutants to associate wit...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141769/ https://www.ncbi.nlm.nih.gov/pubmed/9744888 |