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THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM

1. An equation is derived for the calculation of a constant which, experimental results indicate, may be a more reliable index of the antiproteolytic activity of serum than those equations hitherto used. 2. (a) Intramuscular administration of trypsin resulted in a slow rise in the antiproteolytic ac...

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Detalles Bibliográficos
Autor principal: Grob, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1943
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142560/
https://www.ncbi.nlm.nih.gov/pubmed/19873353
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author Grob, David
author_facet Grob, David
author_sort Grob, David
collection PubMed
description 1. An equation is derived for the calculation of a constant which, experimental results indicate, may be a more reliable index of the antiproteolytic activity of serum than those equations hitherto used. 2. (a) Intramuscular administration of trypsin resulted in a slow rise in the antiproteolytic activity of the serum, followed by a lesser decline. (b) Intravenous administration resulted in no appreciable variation. (c) Oral administration resulted in a rapid rise, which was sustained during the period of administration. (d) Intramuscular, intravenous, or oral administration of denatured trypsin resulted in no appreciable variation. (e) The extent of the local necrosis following subcutaneous injection of trypsin varied inversely with the antiproteolytic activity of the serum. 3. The experimental results indicate that the products of protein hydrolysis in the intestine and parenterally are an important factor in the antiproteolytic activity of the serum. They also indicate that antibodies to trypsin are not an important factor in the antiproteolytic activity of the serum.
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spelling pubmed-21425602008-04-23 THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM Grob, David J Gen Physiol Article 1. An equation is derived for the calculation of a constant which, experimental results indicate, may be a more reliable index of the antiproteolytic activity of serum than those equations hitherto used. 2. (a) Intramuscular administration of trypsin resulted in a slow rise in the antiproteolytic activity of the serum, followed by a lesser decline. (b) Intravenous administration resulted in no appreciable variation. (c) Oral administration resulted in a rapid rise, which was sustained during the period of administration. (d) Intramuscular, intravenous, or oral administration of denatured trypsin resulted in no appreciable variation. (e) The extent of the local necrosis following subcutaneous injection of trypsin varied inversely with the antiproteolytic activity of the serum. 3. The experimental results indicate that the products of protein hydrolysis in the intestine and parenterally are an important factor in the antiproteolytic activity of the serum. They also indicate that antibodies to trypsin are not an important factor in the antiproteolytic activity of the serum. The Rockefeller University Press 1943-03-20 /pmc/articles/PMC2142560/ /pubmed/19873353 Text en Copyright © Copyright, 1943, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Grob, David
THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title_full THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title_fullStr THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title_full_unstemmed THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title_short THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : I. THE NATURE AND EXPERIMENTAL VARIATION OF THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
title_sort antiproteolytic activity of serum : i. the nature and experimental variation of the antiproteolytic activity of serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142560/
https://www.ncbi.nlm.nih.gov/pubmed/19873353
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