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THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION
1. Heating diluted serum at 80° C. for 10 minutes made it a better medium for bacterial growth. This is believed to have been at least partly due to destruction of the serum antiprotease. 2. Growth was accelerated, and proceeded further, in the presence of trypsin. 3. Growth was somewhat retarded in...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1943
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142565/ https://www.ncbi.nlm.nih.gov/pubmed/19873355 |
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author | Grob, David |
author_facet | Grob, David |
author_sort | Grob, David |
collection | PubMed |
description | 1. Heating diluted serum at 80° C. for 10 minutes made it a better medium for bacterial growth. This is believed to have been at least partly due to destruction of the serum antiprotease. 2. Growth was accelerated, and proceeded further, in the presence of trypsin. 3. Growth was somewhat retarded in the presence of pancreatic trypsin inhibitor. 4. The bacteriostatic action of sulfathiazole in serum was reduced by heating the serum at 80° C., and much more markedly (in any of the media studied) by adding trypsin. It was greater in serum and albumen than in peptone and meat infusion. 5. The significance of the experimental results was considered in relation to the possible influence of leucoprotease and of serum antiprotease on bacterial growth and sulfonamide action. |
format | Text |
id | pubmed-2142565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1943 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21425652008-04-23 THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION Grob, David J Gen Physiol Article 1. Heating diluted serum at 80° C. for 10 minutes made it a better medium for bacterial growth. This is believed to have been at least partly due to destruction of the serum antiprotease. 2. Growth was accelerated, and proceeded further, in the presence of trypsin. 3. Growth was somewhat retarded in the presence of pancreatic trypsin inhibitor. 4. The bacteriostatic action of sulfathiazole in serum was reduced by heating the serum at 80° C., and much more markedly (in any of the media studied) by adding trypsin. It was greater in serum and albumen than in peptone and meat infusion. 5. The significance of the experimental results was considered in relation to the possible influence of leucoprotease and of serum antiprotease on bacterial growth and sulfonamide action. The Rockefeller University Press 1943-03-20 /pmc/articles/PMC2142565/ /pubmed/19873355 Text en Copyright © Copyright, 1943, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Grob, David THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title | THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title_full | THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title_fullStr | THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title_full_unstemmed | THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title_short | THE ANTIPROTEOLYTIC ACTIVITY OF SERUM : III. PHYSIOLOGICAL SIGNIFICANCE. THE INFLUENCE OF TRYPSIN AND OF ANTIPROTEASE ON BACTERIAL GROWTH AND SULFONAMIDE ACTION |
title_sort | antiproteolytic activity of serum : iii. physiological significance. the influence of trypsin and of antiprotease on bacterial growth and sulfonamide action |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142565/ https://www.ncbi.nlm.nih.gov/pubmed/19873355 |
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